Early life adversity is associated with a smaller hippocampus in male but not female depressed in-patients: a case–control study

BMC Psychiatry

Research Article

Denis Ducreux¹  Minh Ngoc Thien Kim Tran Dong¹  Olivier Colliot²  Marie Chupin²  Tomoyuki Segawa³  Romain Colle³  Patrick Hardy³  Emmanuelle Corruble³  Bruno Falissard⁴ 

[1] CNRS IR4M, UMR 8081, 94275, Le Kremlin Bicêtre, France;Service de Neuroradiologie, Hôpital Bicêtre, Hôpitaux Universitaires Paris Sud, Assistance Publique Hôpitaux de Paris, 94275, Le Kremlin Bicêtre, France;INSERM U1127, F-75013, Paris, France;CNRS, UMR 7225, 75013, Paris, France;Sorbonne Universités, UPMC Univ. Paris 06, UMR S 1127, F-75013, Paris, France;Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France;Inria, Aramis project-team, Centre de Recherche de Paris, Paris, France;Departments of Neuroradiology and Neurology, AP-HP, Hôpital de la Pitié-Salpêtrière, F-75013, Paris, France;INSERM UMRS 1178, Team “Depression and Antidepressants”, 94275, Le Kremlin Bicêtre, France;Faculté de Médecine Paris Sud, Univ. Paris-Sud, 94275, Le Kremlin Bicêtre, France;Service de Psychiatrie, Hôpital Bicêtre, Hôpitaux Universitaires Paris Sud, Assistance Publique-Hôpitaux de Paris, 94275, Le Kremlin Bicêtre, France;INSERM, Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, Villejuif, France;

关键词: Early life adversity;    Hippocampal volume;    Sex;    Major depressive disorder;    Major depressive episode;    MRI;    Automated segmentation;   

DOI  :  10.1186/s12888-017-1233-2

 received in 2016-10-25, accepted in 2017-02-07,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThree studies assessed the association of early life adversity (ELA) and hippocampal volumes in depressed patients, of which one was negative and the two others did not control for several potential confounding variables. Since the association of ELA and hippocampal volumes differ in male and female healthy volunteers, we investigated the association of ELA and hippocampal volumes in depressed patients, while focusing specifically on sex and controlling for several relevant socio-demographic and clinical variables.MethodsSixty-three depressed in-patients treated in a psychiatric setting, with a current Major Depressive Episode (MDE) and a Major Depressive Disorder (MDD) were included and assessed for ELA. Hippocampal volumes were measured with brain magnetic resonance imaging (MRI) and automatic segmentation. They were compared between patients with (n = 28) or without (n = 35) ELA. After bivariate analyses, multivariate regression analyses tested the interaction of sex and ELA on hippocampal volume and were adjusted for several potential confounding variables. The subgroups of men (n = 26) and women (n = 37) were assessed separately.ResultsPatients with ELA had a smaller hippocampus than those without ELA (4.65 (±1.11) cm3 versus 5.25 (±1.01) cm3), bivariate: p = 0.03, multivariate: HR = 0.40, 95%CI [0.23;0.71], p = 0.002), independently from other factors. This association was found in men (4.43 (±1.22) versus 5.67 (±0.77) cm3), bivariate: p = 0.006, multivariate HR = 0.23, 95%CI [0.06;0.82], p = 0.03) but not in women.ConclusionELA is associated with a smaller hippocampus in male but not female depressed in-patients. The reasons for this association should be investigated in further studies.

【 授权许可】

CC BY   
© The Author(s). 2017