Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume

NEUROBIOLOGY OF AGING

卷:104

Article

Sanchez-Benavides, Gonzalo^1,2,3  Suarez-Calvet, Marc^1,2,3,4  Mila-Aloma, Marta^1,2,3,5  Arenaza-Urquijo, Eider M.^1,2,3  Grau-Rivera, Oriol^1,2,3,4  Operto, Gregory^1,2  Domingo Gispert, Juan^1,2,6  Vilor-Tejedor, Natalia^1,5,7,8  Sala-Vila, Aleix^1,2  Crous-Bou, Marta^1,9,10  Maria Gonzalez-de-Echavarri, Jose^1,2  Minguillon, Carolina^1,2,3  Fauria, Karine^1,3  Simon, Maryline¹¹  Kollmorgen, Gwendlyn¹²  Zetterberg, Henrik^13,14,15,16  Blennow, Kaj^13,14  Luis Molinuevo, Jose^1,17 

[1] Pasqual Maragall Fdn, Barcelonasseta Brain Res Ctr BBRC, Barcelona, Spain

[2] IMIM Hosp del Mar Med Res Inst, Barcelona, Spain

[3] Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid, Spain

[4] Hosp del Mar, Serv Neurol, Barcelona, Spain

[5] Univ Pompeu Fabra, Barcelona, Spain

[6] Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Madrid, Spain

[7] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain

[8] Erasmus MC Univ Med Ctr, Dept Clin Genet, Rotterdam, Netherlands

[9] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[10] Catalan Inst Oncol ICO Bellvitge Biomed Res Inst, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[11] Roche Diagnost Int Ltd, Rotkreuz, Switzerland

[12] Roche Diagnost GmbH, Penzberg, Germany

[13] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[14] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[15] UCL Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England

[16] UCL, UK Dementia Res Inst, London, England

[17] H Lundbeck & Co AS, Copenhagen, Denmark

关键词: Subjective cognitive decline;    Biomarkers;    CSF;    Hippocampal volume;    Neurofilament light;    Amyloid-beta;   

DOI  :  10.1016/j.neurobiolaging.2021.02.026

来源: Elsevier

【 摘 要 】

Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective Cognitive Decline (SCD) and hippocampal volume, and how CSF amyloid-beta (A beta) modifies these associations. We included 278 cognitively unimpaired participants from the Alfa+ cohort (78 SCD and 200 Controls). Linear models accounting for covariates (age, gender, and mood) were used to test the association between CSF NfL and SCD status, and between CSF NfL and bilateral hippocampal volumes. Interactions with A beta were also explored. Individuals with SCD had higher CSF NfL and lower CSF A beta 42/40 than Controls. There was a significant interaction between SCD and CSF-A beta 42/40 levels. Stratified analyses showed a significant association between SCD and NfL only in A beta+ individuals. Higher CSF NfL was significantly associated with lower hippocampal volume specifically in A beta+ individuals with SCD. The presence of SCD in A beta+ individuals may represent an early symptom in the Alzheimer's continuum related to incipient neurodegeneration. (C) 2021 The Authors. Published by Elsevier Inc.

【 授权许可】

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