Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy

BMC Cancer

Study Protocol

H. Rundqvist¹  Y. Wengström²  M. Backman²  S. Mijwel³  J. Norrbom³  C. J. Sundberg⁴  M. Browall⁵  K. A. Bolam⁶ 

[1] Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;Department of Neurobiology, Care Science and Society, Division of Nursing, Karolinska Institutet, Karolinska University Hospital, 141 83 Huddinge, Stockholm, Sweden;Department of Oncology, Karolinska University Hospital, Stockholm, Sweden;Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden;Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden;Unit for Bioentrepreneurship, Karolinska Institutet, Solna, Sweden;School of Health and Education, University of Skövde, Skövde, Sweden;Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden;School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia;

关键词: Patients with breast cancer;    Exercise intervention;    Chemotherapy;    Fatigue;    Inflammation;    Skeletal muscle;   

DOI  :  10.1186/s12885-017-3079-x

 received in 2016-07-12, accepted in 2017-01-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWomen with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve physical function as well as quality of life. The primary aim of the study is to investigate and compare the effects of two different exercise regimens on the primary outcome cancer-related fatigue and the secondary outcomes muscle strength, function and structure, cardiovascular fitness, systemic inflammation, skeletal muscle gene activity, health related quality of life, pain, disease and treatment-related symptoms in women with breast cancer receiving chemotherapy. The second aim is to examine if any effects are sustained 1, 2, and 5 years following the completion of the intervention and to monitor return to work, recurrence and survival. The third aim of the study is to examine the effect of attendance and adherence rates on the effects of the exercise programme.MethodsThis study is a randomised controlled trial including 240 women with breast cancer receiving chemotherapy in Stockholm, Sweden. The participants are randomly allocated to either: group 1: Aerobic training, group 2: Combined resistance and aerobic training, or group 3: usual care (control group). During the 5-year follow-up period, participants in the exercise groups will receive a physical activity prescription. Measurements for endpoints will take place at baseline, after 16 weeks (end of intervention) as well as after 1, 2 and 5 years.DiscussionThis randomised controlled trial will generate substantial information regarding the effects of different types of exercise on the health of patients with breast cancer undergoing chemotherapy. We expect that dissemination of the knowledge gained from this study will contribute to developing effective long term strategies to improve the physical and psychosocial health of breast cancer survivors.Trial registrationOptiTrain - Optimal Training Women with Breast Cancer (OptiTrain), NCT02522260; Registration: June 9, 2015, Last updated version Feb 29, 2016. Retrospectively registered.

【 授权许可】

CC BY   
© The Author(s). 2017