Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry

BMC Cardiovascular Disorders

Research Article

Wolfgang Schöls¹  Thomas Dorsel²  Joachim Thale³  Hermann R Ochs⁴  Franz Josef Hegge⁵  Hubertus Heuer⁶  Wilfried Dinh⁷  Georg Haltern⁷  Hartmut Gülker⁷  Wolfgang Motz⁸  Christoph Stellbrink⁹  Silke Kullmann^1,10  Priska Binner^1,10  Thomas Scheffold^1,10  Andreas Huge^1,11  Monika Stoll^1,11 

[1] Department of Cardiology, Heart Centre Duisburg, 47137, Duisburg, Germany;Department of Angiology, Heart Centre Duisburg, 47137, Duisburg, Germany;Department of Cardiology, Josephs-Hospital Warendorf, 48231, Warendorf, Germany;Department of Cardiology, Schüchtermann-Klinik, Heart Centre Osnabrück-Bad Rothenfelde, 49214, Bad Rothenfelde, Germany;Department of Internal Medicine, Marienkrankenhaus Soest, 59494, Soest, Germany;Department of Internal Medicine, St. Christophorus-Krankenhaus Werne, 59368, Werne, Germany;Department of Internal Medicine, St. Johannes Hospital Dortmund, 44227, Dortmund, Germany;Heart Centre Wuppertal Helios-Kliniken, 42117, Wuppertal, Germany;Heart and Diabetes Centre Mecklenburg-Vorpommern, Klinikum Karlsburg, 17495, Karlsburg, Germany;Hospital for Cardiology and Internal Intensive Care, Städtische Kliniken Bielefeld-Mitte, 33604, Bielefeld, Germany;Institute for Heart and Circulation Research, University of Witten/Herdecke, 44227, Dortmund, Germany;Leibniz-Institute for Arteriosclerosis Research, University of Münster, 48149, Münster, Germany;

关键词: Coronary Artery Disease;    Myocardial Infarction;    Acute Coronary Syndrome;    Single Nucleotide Polymorphism;    Positive Family History;   

DOI  :  10.1186/1471-2261-11-9

 received in 2010-09-10, accepted in 2011-03-07,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundRecent genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) and myocardial infarction (MI). The 9p21.3 locus was verified by numerous replication studies to be the first common locus for CAD and MI. In the present study, we investigated whether six single nucleotide polymorphisms (SNP) rs1333049, rs1333040, rs10757274, rs2383206, rs10757278, and rs2383207 representing the 9p21.3 locus were associated with the incidence of an acute MI in patients with the main focus on the familial aggregation of the disease.MethodsThe overall cohort consisted of 976 unrelated male patients presenting with an acute coronary syndrome (ACS) with ST-elevated (STEMI) as well as non-ST-elevated myocardial infarction (NSTEMI). Genotyping data of the investigated SNPs were generated and statistically analyzed in comparison to previously published findings of matchable control cohorts.ResultsStatistical evaluation confirmed a highly significant association of all analyzed SNP's with the occurrence of MI (p < 0.0001; OR: 1.621-2.039). When only MI patients with a positive family disposition were comprised in the analysis a much stronger association of the accordant risk alleles with incident disease was found with odds ratios up to 2.769.ConclusionsThe findings in the present study confirmed a strong association of the 9p21.3 locus with MI particularly in patients with a positive family history thereby, emphasizing the pathogenic relevance of this locus as a common genetic cardiovascular risk factor.

【 授权许可】

CC BY   
© Scheffold et al; licensee BioMed Central Ltd. 2011