Does cartilage volume measurement or radiographic osteoarthritis at baseline independently predict ten-year cartilage volume loss?

BMC Musculoskeletal Disorders

Research Article

Flavia Cicuttini¹  Andrew McBride²  Hussain Ijaz Khan²  Graeme Jones²  Louisa Chou²  Dawn Aitken²  Changhai Ding²  Leigh Blizzard²  Jean-Pierre Pelletier³  Johanne Martel-Pelletier³ 

[1] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia;Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17-Liverpool Street, 7000, Hobart, Australia;Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada;

关键词: Knee;    Osteoarthritis;    Cartilage volume;    Magnetic resonance imaging;    Radiographs;   

DOI  :  10.1186/s12891-016-0900-7

 received in 2015-07-28, accepted in 2016-01-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to examine whether cartilage volume as measured by MRI and radiographic osteoarthritis (OA) at baseline predict cartilage volume loss over ten years independent of each other and other structural co-pathologies.Methods219 participants [mean-age 45(26–61); 57 % female] were studied at baseline and ten years. Approximately half were the adult offspring of subjects who underwent knee replacement for OA and the remainder were randomly selected controls. Joint space narrowing (JSN) and osteophytes were assessed on radiographs and cartilage volume (tibiofemoral), cartilage defects, bone marrow lesions and meniscal tears/extrusion were assessed on MRI.ResultsMean absolute and percentage per annum cartilage volume loss was 1284 mm3 and 1.91 % respectively in the medial compartment and 1007 mm3 and 1.38 % respectively in the lateral compartment. Higher baseline tibiofemoral cartilage volume was independently associated with greater absolute cartilage volume loss in both medial (β(95 % CI) = −300 (−399,−200)) and lateral (β = −338 (−443,−233)) compartments and percentage per annum loss in the lateral compartment(β = −0.15 (−0.29, −0.01)). Baseline JSN and osteophytes were associated with cartilage volume loss in the univariable analysis, however these associations did not persist after adjustment for other structural co-pathologies.ConclusionCross-sectional cartilage volume measurement independently predicts cartilage volume loss over 10 years and can be used to identify fast progressors in clinical trials. Radiographic JSN and osteophytes on the other hand are a reflection of other co-pathologies assessed on MRI and do not independently predict cartilage volume loss over 10 years.

【 授权许可】

CC BY   
© McBride et al. 2016