Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI

Arthritis Research & Therapy

Emily J. McWalter¹  Duncan E. Meuffels²  Gabriel P. Krestin³  Edwin H. G. Oei³  Bas A. de Vries³  Stephan J. Breda⁴  Bragi Sveinsson⁵  Brian A. Hargreaves⁶  Garry E. Gold⁶ 

[1] Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada;Department of Orthopedic Surgery, Erasmus MC, Rotterdam, The Netherlands;Department of Radiology & Nuclear Medicine, Erasmus MC, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands;Department of Radiology & Nuclear Medicine, Erasmus MC, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands;Department of Orthopedic Surgery, Erasmus MC, Rotterdam, The Netherlands;Department of Radiology, Massachusetts General Hospital, Boston, USA;Harvard Medical School, Boston, USA;Department of Radiology, Stanford University, Stanford, USA;

关键词: Osteoarthritis;    Knee;    Synovitis;    Magnetic resonance imaging;    Inflammation;    Humans;   

DOI  :  10.1186/s13075-021-02436-8

来源: Springer

【 摘 要 】

BackgroundTo assess diagnostic accuracy of quantitative double-echo in steady-state (qDESS) MRI for detecting synovitis in knee osteoarthritis (OA).MethodsPatients with different degrees of radiographic knee OA were included prospectively. All underwent MRI with both qDESS and contrast-enhanced T1-weighted magnetic resonance imaging (CE-MRI). A linear combination of the two qDESS images can be used to create an image that displays contrast between synovium and the synovial fluid. Synovitis on both qDESS and CE-MRI was assessed semi-quantitatively, using a whole-knee synovitis sum score, indicating no/equivocal, mild, moderate, and severe synovitis. The correlation between sum scores of qDESS and CE-MRI (reference standard) was determined using Spearman’s rank correlation coefficient and intraclass correlation coefficient for absolute agreement. Receiver operating characteristic analysis was performed to assess the diagnostic performance of qDESS for detecting different degrees of synovitis, with CE-MRI as reference standard.ResultsIn the 31 patients included, very strong correlation was found between synovitis sum scores on qDESS and CE-MRI (ρ = 0.96, p < 0.001), with high absolute agreement (0.84 (95%CI 0.14–0.95)). Mean sum score (SD) values on qDESS 5.16 (3.75) were lower than on CE-MRI 7.13 (4.66), indicating systematically underestimated synovitis severity on qDESS. For detecting mild synovitis or higher, high sensitivity and specificity were found for qDESS (1.00 (95%CI 0.80–1.00) and 0.909 (0.571–1.00), respectively). For detecting moderate synovitis or higher, sensitivity and specificity were good (0.727 (95%CI 0.393–0.927) and 1.00 (0.800–1.00), respectively).ConclusionqDESS MRI is able to, however with an underestimation, detect synovitis in patients with knee OA.

【 授权许可】

CC BY