Influences of laparoscopic-assisted gastrectomy and open gastrectomy on serum interleukin-6 levels in patients with gastric cancer among Asian populations: a systematic review

BMC Gastroenterology

Research Article

Yong-Chao Li¹  Li-Bo Sun¹  Zhen-Bo Shu¹  Hai-Ping Cao² 

[1] Department of Gastrointestinal Surgery, China-Japan Union Hospital, Jilin University, Xiantai Main Street No.126, 130033, Changchun, China;Department of Nephrology, China-Japan Union Hospital, Jilin University, 130033, Changchun, China;

关键词: Laparoscopic-assisted gastrectomy;    Open gastrectomy;    Gastric cancer;    Interleukin-6;    Serum levels;    Inflammatory reaction;    Clinical cohort studies;    Meta-analysis;   

DOI  :  10.1186/s12876-015-0276-4

 received in 2014-12-19, accepted in 2015-03-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundTo compare the effects of laparoscopic-assisted gastrectomy (LAG) and open gastrectomy (OG) on serum interleukin-6 (IL-6) levels in gastric cancer (GC) patients from Asia.MethodsThe following scientific literature databases were searched for relevant clinical studies: PubMed, EBSCO, Ovid, Wiley, Web of Science, Cochrane library, EMBASE, WANFANG and VIP databases. The studies retrieved from database searches were screened based on stringent inclusion and exclusion criteria to select high quality cohort studies for the present meta-analysis. The data extracted from final selected studies were analyzed using STATA 12.0 software.ResultsA total of 54 studies were initially retrieved from database searches, and 11 clinical cohort studies were eventually enrolled in this meta-analysis. The 11 selected studies contained a combined total of 767 GC patients (427 patients in LAG group and 340 patients in OG group). Meta-analysis results demonstrated that postoperative serum IL-6 levels in GC patients in LAG group was significantly lower than the OG group (SMD = −2.16, 95% CI = −3.19 ~ −1.14, P < 0.001). The difference in serum IL-6 levels between the preoperative and postoperative GC patients was significantly lower in the LAG group compared to the difference found in the OG group (SMD = −3.44, 95% CI = −4.87 ~ −2.01, P < 0.001). Subgroup analysis based on country showed that, in both Chinese and Japanese GC patients, the postoperative increase in serum IL-6 levels in LAG group were significantly lower than the increase observed in the OG group (all P < 0.05). In Korean GC patients, the postoperative increase in serum IL-6 levels was not significantly different between the LAG group and OG group (all P > 0.05).ConclusionOur results provide strong evidence that LAG is associated with significantly lower serum IL-6 levels, compared to OG. Thus, LAG carries markedly lower risk of adverse inflammatory reactions in GC patients among Asian population.

【 授权许可】

Unknown   
© Shu et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.