Tumor budding as a risk factor of lymph node metastasis in submucosal invasive T1 colorectal carcinoma: a retrospective study

BMC Surgery

Research Article

Ji-Han Jung¹  Jun-Gi Kim²  Hyeon-Min Cho³  Se-Goo Kang³  Hyung-Jin Kim³  Bong-Hyeon Kye³ 

[1] Department of Pathology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93-6, Ji-dong, Paldal-gu, 442-723, Suwon-si, Gyeonggi-do, South Korea;Department of Surgery, Seoul St. Mary’s Hopsital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, South Korea;Department of Surgery, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93-6, Ji-dong, Paldal-gu, 442-723, Suwon-si, Gyeonggi-do, South Korea;

关键词: Lymph node metastasis;    T1 colorectal cancer;    Tumor budding;   

DOI  :  10.1186/1471-2482-12-16

 received in 2012-01-16, accepted in 2012-08-03,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThis study was designed to identify risk factors for lymph node metastasis of early stage colorectal cancer, which was confirmed to a carcinoma that invaded the submucosa after radical resection.MethodsIn total, 55 patients revealing submucosal invasive colorectal carcinoma on pathology who underwent curative radical resection at the Department of Surgery, St. Vincent’s Hospital, The Catholic University of Korea from January 2007 to September 2010 were evaluated retrospectively. Tumor size, depth of submucosal invasion, histologic grade, lymphovascular invasion, tumor budding, and microacinar structure were reviewed by a single pathologist. Student t-test for continuous variables and Chi-square test for categorical variables were used for comparing the clinicopathological features between two groups (whether lymph node involvement existed or not). Continuous variables are expressed as the mean ± standard error while statistical significance is accepted at P < 0.05.ResultsThe mean age of 55 patients (34 males and 21 females) was 61.2 ± 9.6 years (range, 43–83). Histologically, eight (14.5%) patients had metastatic lymph node. In the univariate analysis, tumor budding (P = 0.047) was the only factor that was significantly associated with lymph node metastasis. Also, the tumor budding had a sensitivity of 83.3%, a specificity of 60.5%, and a negative predictive value of 0.958 for lymph node metastasis in submucosal invasive T1 colorectal cancer.ConclusionsThe tumor budding seems to have a high sensitivity (83.3%), acceptable specificity (60.5%), and a high negative predictive value (0.958). A close examination of pathologic finding including tumor budding should be performed in order to manage early CRC properly.

【 授权许可】

Unknown   
© Kye et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.