The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis

BMC Endocrine Disorders

Research Article

Lars Berglund¹  Fernando Coto-Yglesias²  Svitlana Dzyubak²  Melanie A Lane²  Patricia J Erwin²  Tarig Elraiyah²  Shabnum Gupta²  Irina Bancos³  Victor M Montori³  M Hassan Murad⁴  Ahmad Hazem⁵ 

[1] Davis and the VA Northern California Health Care System, University of California, Sacramento, USA;Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA;Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA;Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN, USA;Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA;Division of Preventive Medicine, Mayo Clinic, Rochester, MN, USA;Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA;Division of Preventive Medicine, Mayo Clinic, Rochester, MN, USA;Department of Internal Medicine, University of North Dakota, Fargo, ND, USA;

关键词: Hypertriglyceridemia;    Cardiovascular disease;    Pancreatitis;    Systematic reviews and meta-analysis;   

DOI  :  10.1186/1472-6823-12-2

 received in 2012-01-06, accepted in 2012-03-31,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundHypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.MethodsWe conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.Results35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.ConclusionsThe current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis

【 授权许可】

CC BY   
© Murad et al; licensee BioMed Central Ltd. 2012