Organic Cation Transporter 1 (OCT1) mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatment

BMC Cancer

Research Article

Sandra Koch¹  Arndt Weinmann¹  Tim Zimmermann¹  Jonas Lieb¹  Jörn M. Schattenberg¹  Marcus A. Wörns¹  Peter R. Galle¹  Felix Darstein¹  Daniel Grimm¹  Johanna Vollmar¹  Maria Hoppe-Lotichius²  Anja Lautem²  Arno Schad³  Veronika Weyer⁴ 

[1] 1st Department of Medicine, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany;Department of General-, Visceral- and Transplantation Surgery, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany;Department of Pathology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany;University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics, Obere Zahlbacher Str. 69, 55131, Mainz, Germany;

关键词: Hepatocellular carcinoma;    HCC;    OCT1;    SLC22A1;    Biomarker;    Sorafenib;   

DOI  :  10.1186/s12885-016-2150-3

 received in 2015-07-15, accepted in 2016-02-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe polyspecific organ cation transporter 1 (OCT1) is one of the most important active influx pumps for drugs like the kinase inhibitor sorafenib. The aim of this retrospective study was the definition of the role of intratumoral OCT1 mRNA expression in hepatocellular carcinoma (HCC) as a biomarker in systemic treatment with sorafenib.MethodsOCT1 mRNA expression levels were determined in biopsies from 60 primary human HCC by real time PCR. The data was retrospectively correlated with clinical parameters.ResultsIntratumoral OCT1 mRNA expression is a significant positive prognostic factor for patients treated with sorafenib according to Cox regression analysis (HR 0.653, 95 %-CI 0.430-0.992; p = 0.046). Under treatment with sorafenib, a survival benefit could be shown using the lower quartile of intratumoral OCT1 expression as a cut-off. Macrovascular invasion (MVI) was slightly more frequent in patients with low OCT1 mRNA expression (p = 0.037). Treatment-induced AFP response was not associated with intratumoral OCT1 mRNA expression levels (p = 0.633).ConclusionsThis study indicates a promising role for intratumoral OCT1 mRNA expression as a prognostic biomarker in therapeutic algorithms in HCC. Further prospective studies are warranted on this topic.

【 授权许可】

CC BY   
© Grimm et al. 2016