Association in a Chinese population of a genetic variation in the early B-cell factor 1 gene with coronary artery disease

BMC Cardiovascular Disorders

Research Article

Zhong Chen¹  Yao Ma²  Yafei Li²  Jianjun Yan²  Zhiyong Xie²  Liansheng Wang²  Lei Chen³ 

[1] Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital East Campus, No. 222 Huanhu Xisan Road, Pudong New Area, 201306, Shanghai, China;Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gu Lou Area, 210029, Nanjing, China;Department of Cardiology, Xuzhou Medical University, NO.209 Tongshan Road, 221000, Xuzhou, China;

关键词: Early B-cell factor 1;    Genetic polymorphism;    Coronary artery disease;    Risk assessment;   

DOI  :  10.1186/s12872-017-0489-2

 received in 2016-09-02, accepted in 2017-02-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundEarly B-cell factor 1 (EBF1) is a transcription factor expressed primarily during early B cell development. Previous studies have shown EBF1 regulates blood glucose and lipid metabolism in mice with diabetes and central adiposity. Recently, a genetic variation (rs36071027) located in an EBF1 gene intron was associated with carotid artery intima-media thickness. However, whether this polymorphism is actually linked with coronary artery disease (CAD) and its severity remains unclear.MethodsThis study includes 293 CAD cases and 262 controls without CAD. All participants were devided into two groups based on their coronary angiography results. A polymerase chain reaction-ligase detection reaction was used to identify genotypes at rs36071027, and CAD patients were further divided into subgroups with one-, two-, or three-vessel stenosis reflective of CAD severity.ResultsThe frequency of the rs36071027 TT genotype was significantly higher in CAD cases versus controls (4.8% vs. 1.5%, 95% CI: 1.13-10.81 P = 0.029). Subjects with a variant genotype T allele had an increased risk of CAD compared to C allele carriers (additive model: 95% CI: 1.13-2.23, P = 0.008). After adjustment for cardiovascular risk factors, analysis of the additive and dominant models involving rs36071027 also revealed that T allele carriers had a significantly higher risk for CAD than C allele carriers (additive model: OR 1.56, 95% CI 1.10–2.22, P = 0.013; dominant model: OR 1.60, 95% CI 1.07–2.41, P = 0.023). Furthermore, both diabetes and the CT + TT rs36071027 genotype were significantly associated with three-vessel stenosis.ConclusionOur results in a Chinese population suggest that the TT genotype and T alleles in rs36071027 in the EBF1 gene are associated with an increased risk of CAD and its severity.

【 授权许可】

CC BY   
© The Author(s). 2017