Association of hypertension with physical factors of wrist pulse waves using a computational approach: a pilot study

BMC Complementary and Alternative Medicine

Research Article

Jong Yeol Kim¹  Jang-Han Bae¹  Young Ju Jeon¹  Bum Ju Lee¹  Boncho Ku¹  Jaeuk U. Kim¹ 

[1] KM Fundamental Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, 305-811, Yuseong-gu, Deajeon, Republic of Korea;

关键词: Wrist pulse wave;    Hypertension;    Physical factors;    Computational approach;    Quantification;    Objectification;    Traditional Chinese Medicine (TCM);    Traditional Korean Medicine (TKM);   

DOI  :  10.1186/s12906-015-0756-7

 received in 2015-04-02, accepted in 2015-06-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe objectives of this pilot study were to examine the association between hypertension and physical factors of wrist pulse waves to avoid subjective diagnoses in Traditional Chinese Medicine (TCM) and Traditional Korean Medicine (TKM). An additional objective was to assess the predictive power of individual and combined physical factors in order to identify the degree of agreement between diagnosis accuracies using physical factors and using a sphygmomanometer in the prediction of hypertension.MethodsIn total, 393 women aged 46 to 73 years participated in this study. Logistic regression (LR) and a naïve Bayes algorithm (NB) were used to assess statistically significant differences and the predictive power of hypertension, and a wrapper-based machine learning method was used to evaluate the predictive power of combinations of physical factors.ResultsIn both wrists, L-PPI and R-PPI (maximum pulse amplitudes in the left Gwan and right Gwan) were the factors most strongly associated with hypertension after adjusting for age and body mass index (p = <0.001, odds ratio (OR) = 2.006 on the left and p = <0.001, OR = 2.504 on the right), and the best predictors (NB-AUC = 0.692, LR-AUC = 0.7 on the left and NB-AUC = 0.759, LR-AUC = 0.763 on the right). Analyses of both individual and combined physical factors revealed that the predictive power of the physical factors in the right wrist was higher than for the left wrist. The predictive powers of the combined physical factors were higher than those of the best single predictors in both the left and right wrists.ConclusionWe suggested new physical factors related to the sum of the area on the particular region of pulse waves in both wrists. L-PPI and R-PPI among all variables used in this study were good indicators of hypertension. Our findings support the quantification and objectification of pulse patterns and disease in TCM and TKM for complementary and alternative medicine.

【 授权许可】

Unknown   
© Lee et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.