A pilot study of transrectal endoscopic ultrasound elastography in inflammatory bowel disease

BMC Gastroenterology

Research Article

Marko Brinar¹  Davor Radić¹  Rajko Ostojic¹  Nadan Rustemovic¹  Silvija Cukovic-Cavka¹  Milorad Opacic¹  Boris Vucelic¹ 

[1] Department of Gastroenterology University Hospital Centre Zagreb, Croatia;

关键词: Crohn's disease;    ulcerative colitis;    elastography;    ultrasound;   

DOI  :  10.1186/1471-230X-11-113

 received in 2011-05-25, accepted in 2011-10-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundUsing standard diagnostic algorithms it is not always possible to establish the correct phenotype of inflammatory bowel disease which is essential for therapeutical decisions. Endoscopic ultrasound elastography is a new endoscopic procedure which can differentiate the stiffness of normal and pathological tissue by ultrasound. Therefore, we aimed to investigate the role of transrectal ultrasound elastography in distiction between Crohn's disease and ulcerative colitis.MethodsA total 30 Crohn's disease, 25 ulcerative colitis, and 28 non-inflammatory bowel disease controls were included. Transrectal ultrasound elastography was performed in all patients and controls. In all ulcerative coltis patients and 80% of Crohn's disease patients endoscopy was performed to assess disease activity in the rectum.ResultsSignificant difference in rectal wall thickness and strain ratio was detected between patients with Crohn's disease and controls (p = 0.0001). CD patients with active disease had higher strain ratio than patients in remission (p = 0.02). In ulcerative colitis group a significant difference in rectal wall thickness was found between controls and patients with active disease (p = 0.03). A significant difference in rectal wall thickness (p = 0.02) and strain ratio (p = 0.0001) was detected between Crohn's disease and ulcerative colitis patient group. Crohn's disease patients with active disease had a significantly higher strain ratio compared to ulcerative colitis patients with active disease (p = 0.0001).ConclusionTransrectal ultrasound elastography seems to be a promising new diagnostic tool in the field of inflammatory bowel disease. Further study on a larger cohort of patients is needed to definitely assess the role of transrectal ultrasound elastography in inflammatory bowel disease.

【 授权许可】

CC BY   
© Rustemovic et al; licensee BioMed Central Ltd. 2011