A pilot study of transrectal endoscopic ultrasound elastography in inflammatory bowel disease

BMC Gastroenterology

Boris Vucelic¹  Rajko Ostojic¹  Milorad Opacic¹  Davor Radić¹  Marko Brinar¹  Silvija Cukovic-Cavka¹  Nadan Rustemovic¹ 

[1] Department of Gastroenterology University Hospital Centre Zagreb, Croatia

关键词: ultrasound;    elastography;    ulcerative colitis;    Crohn's disease;   

Others  :  1113228
DOI  :  10.1186/1471-230X-11-113

 received in 2011-05-25, accepted in 2011-10-20,  发布年份 2011

【 摘 要 】

Background

Using standard diagnostic algorithms it is not always possible to establish the correct phenotype of inflammatory bowel disease which is essential for therapeutical decisions. Endoscopic ultrasound elastography is a new endoscopic procedure which can differentiate the stiffness of normal and pathological tissue by ultrasound. Therefore, we aimed to investigate the role of transrectal ultrasound elastography in distiction between Crohn's disease and ulcerative colitis.

Methods

A total 30 Crohn's disease, 25 ulcerative colitis, and 28 non-inflammatory bowel disease controls were included. Transrectal ultrasound elastography was performed in all patients and controls. In all ulcerative coltis patients and 80% of Crohn's disease patients endoscopy was performed to assess disease activity in the rectum.

Results

Significant difference in rectal wall thickness and strain ratio was detected between patients with Crohn's disease and controls (p = 0.0001). CD patients with active disease had higher strain ratio than patients in remission (p = 0.02). In ulcerative colitis group a significant difference in rectal wall thickness was found between controls and patients with active disease (p = 0.03). A significant difference in rectal wall thickness (p = 0.02) and strain ratio (p = 0.0001) was detected between Crohn's disease and ulcerative colitis patient group. Crohn's disease patients with active disease had a significantly higher strain ratio compared to ulcerative colitis patients with active disease (p = 0.0001).

Conclusion

Transrectal ultrasound elastography seems to be a promising new diagnostic tool in the field of inflammatory bowel disease. Further study on a larger cohort of patients is needed to definitely assess the role of transrectal ultrasound elastography in inflammatory bowel disease.

【 授权许可】

   
2011 Rustemovic et al; licensee BioMed Central Ltd.

【 图 表 】

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