Young coconut juice can accelerate the healing process of cutaneous wounds

BMC Complementary and Alternative Medicine

Research Article

Farid Saleh¹  Patchara Subhadhirasakul²  Nisaudah Radenahmad²  Piyakorn Boonyoung²  Winyou Mitranun³  Wilart Rundorn⁴  Kitja Sawangjaroen⁴  Ibrahim Sayoh⁵ 

[1] Department of Anatomy, College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University, 13317-4233, Riyadh, Saudi Arabia;Department of Anatomy, Prince of Songkla University, 90112, Hat Yai, Thailand;Department of Pathology, Faculty of Medicine, Prince of Songkla University, 90112, Hat Yai, Thailand;Department of Pharmacology, Faculty of Science, Prince of Songkla University, 90112, Hat Yai, Thailand;Faculty of Science and Technology, Princess of Naradhiwas University, 96000, Narathiwat, Thailand;

关键词: Young coconut juice;    Wound healing;    Estrogen;    ER-α;    ER-β;    Ovariectomy;   

DOI  :  10.1186/1472-6882-12-252

 received in 2012-07-22, accepted in 2012-12-06,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundEstrogen has been reported to accelerate cutaneous wound healing. This research studies the effect of young coconut juice (YCJ), presumably containing estrogen-like substances, on cutaneous wound healing in ovairectomized rats.MethodsFour groups of female rats (6 in each group) were included in this study. These included sham-operated, ovariectomized (ovx), ovx receiving estradiol benzoate (EB) injections intraperitoneally, and ovx receiving YCJ orally. Two equidistant 1-cm full-thickness skin incisional wounds were made two weeks after ovariectomy. The rats were sacrificed at the end of the third and the fourth week of the study, and their serum estradiol (E2) level was measured by chemiluminescent immunoassay. The skin was excised and examined in histological sections stained with H&E, and immunostained using anti-estrogen receptor (ER-α an ER-β) antibodies.ResultsWound healing was accelerated in ovx rats receiving YCJ, as compared to controls. This was associated with significantly higher density of immunostaining for ER-α an ER-β in keratinocytes, fibroblasts, white blood cells, fat cells, sebaceous gland, skeletal muscles, and hair shafts and follicles. This was also associated with thicker epidermis and dermis, but with thinner hypodermis. In addition, the number and size of immunoreactive hair follicles for both ER-α and ER-β were the highest in the ovx+YCJ group, as compared to the ovx+EB group.ConclusionsThis study demonstrates that YCJ has estrogen-like characteristics, which in turn seem to have beneficial effects on cutaneous wound healing.

【 授权许可】

CC BY   
© Radenahmad et al.; licensee BioMed Central Ltd. 2012