Young coconut juice can accelerate the healing process of cutaneous wounds

BMC Complementary and Alternative Medicine

Winyou Mitranun²  Wilart Rundorn⁵  Piyakorn Boonyoung¹  Patchara Subhadhirasakul¹  Kitja Sawangjaroen⁵  Ibrahim Sayoh⁴  Farid Saleh³  Nisaudah Radenahmad¹ 

[1] Department of Anatomy, Prince of Songkla University, Hat Yai, 90112, Thailand;Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90112, Thailand;Department of Anatomy, College of Medicine, Al-Imam Muhammad Ibn Saud Islamic University, Riyadh, 13317-4233, Kingdom of Saudi Arabia;Faculty of Science and Technology, Princess of Naradhiwas University, Narathiwat, 96000, Thailand;Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, 90112, Thailand

关键词: Ovariectomy;    ER-β;    ER-α;    Estrogen;    Wound healing;    Young coconut juice;   

Others  :  1231373
DOI  :  10.1186/1472-6882-12-252

 received in 2012-07-22, accepted in 2012-12-06,  发布年份 2012

【 摘 要 】

Background

Estrogen has been reported to accelerate cutaneous wound healing. This research studies the effect of young coconut juice (YCJ), presumably containing estrogen-like substances, on cutaneous wound healing in ovairectomized rats.

Methods

Four groups of female rats (6 in each group) were included in this study. These included sham-operated, ovariectomized (ovx), ovx receiving estradiol benzoate (EB) injections intraperitoneally, and ovx receiving YCJ orally. Two equidistant 1-cm full-thickness skin incisional wounds were made two weeks after ovariectomy. The rats were sacrificed at the end of the third and the fourth week of the study, and their serum estradiol (E2) level was measured by chemiluminescent immunoassay. The skin was excised and examined in histological sections stained with H&E, and immunostained using anti-estrogen receptor (ER-α an ER-β) antibodies.

Results

Wound healing was accelerated in ovx rats receiving YCJ, as compared to controls. This was associated with significantly higher density of immunostaining for ER-α an ER-β in keratinocytes, fibroblasts, white blood cells, fat cells, sebaceous gland, skeletal muscles, and hair shafts and follicles. This was also associated with thicker epidermis and dermis, but with thinner hypodermis. In addition, the number and size of immunoreactive hair follicles for both ER-α and ER-β were the highest in the ovx+YCJ group, as compared to the ovx+EB group.

Conclusions

This study demonstrates that YCJ has estrogen-like characteristics, which in turn seem to have beneficial effects on cutaneous wound healing.

【 授权许可】

   
2012 Radenahmad et al.; licensee BioMed Central Ltd.

【 图 表 】

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