Brain responses to body image stimuli but not food are altered in women with bulimia nervosa

BMC Psychiatry

Research Article

Iain C Campbell¹  Ulrike Schmidt¹  Rudolf Uher²  Frederique Van den Eynde³  Philippe-Olivier Harvey⁴  Vincent Giampietro⁵  Chris M Andrew⁵  Andrew Simmons⁶ 

[1] Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King’s College London, London, UK;Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King’s College London, London, UK;Department of Psychiatry, Dalhousie University, Halifax, NS, Canada;Department of Psychological Medicine, Section of Eating Disorders Institute of Psychiatry, King’s College London, London, UK;Eating Disorders Program, Douglas Mental Health University Institute and McGill University, Montréal, Québec, Canada;Institute of Psychiatry, King’s College London, PO Box 59, De Crespigny Park, SE5 8AF, London, UK;Douglas Mental Health University Institute and McGill University, Montréal, Québec, Canada;Institute of Psychiatry, Department of Neuroimaging, King’s College London, London, UK;Institute of Psychiatry, Department of Neuroimaging, King’s College London, London, UK;NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King’s College London, London, UK;

关键词: Functional magnetic resonance imaging;    Bulimia nervosa;    Insula;    Anxiety;    Craving;   

DOI  :  10.1186/1471-244X-13-302

 received in 2013-05-23, accepted in 2013-09-03,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundResearch into the neural correlates of bulimia nervosa (BN) psychopathology remains limited.MethodsIn this functional magnetic resonance imaging study, 21 BN patients and 23 healthy controls (HCs) completed two paradigms: 1) processing of visual food stimuli and 2) comparing their own appearance with that of slim women. Participants also rated food craving and anxiety levels.ResultsBrain activation patterns in response to food cues did not differ between women with and without BN. However, when evaluating themselves against images of slim women, BN patients engaged the insula more and the fusiform gyrus less, compared to HCs, suggesting increased self-focus among women with BN whilst comparing themselves to a ‘slim ideal’. In these BN patients, exposure to food and body image stimuli increased self-reported levels of anxiety, but not craving.ConclusionsOur findings suggest that women with BN differ from HCs in the way they process body image, but not in the way they process food stimuli.

【 授权许可】

CC BY   
© Van den Eynde et al.; licensee BioMed Central Ltd. 2013