The epidemiology and transmission of methicillin-resistant Staphylococcus aureus in the community in Singapore: study protocol for a longitudinal household study

BMC Infectious Diseases

Study Protocol

Paola Florez De Sessions¹  Balamurugan Periaswamy¹  Desmond B. Teo²  Paul A. Tambyah²  Jolene Oon²  Nivedita Shankar³  Junxiong Pang³  Clarence C. Tam⁴  Li Yang Hsu⁵  Angela Li Ping Chow⁶  Brenda Ang⁶ 

[1] Genome Institute of Singapore, Singapore, Singapore;National University Hospital, Singapore, Singapore;Saw Swee Hock School of Public Health, Tahir Foundation Building, 12 Science Drive 2, 11-01, 117549, Singapore, Singapore;Saw Swee Hock School of Public Health, Tahir Foundation Building, 12 Science Drive 2, 11-01, 117549, Singapore, Singapore;London School of Hygiene and Tropical Medicine, London, UK;Saw Swee Hock School of Public Health, Tahir Foundation Building, 12 Science Drive 2, 11-01, 117549, Singapore, Singapore;Tan Tock Seng Hospital, Singapore, Singapore;Tan Tock Seng Hospital, Singapore, Singapore;

关键词: Cohort studies;    Longitudinal studies;    MRSA;    Staphylococcus aureus;    Methicillin;    Antimicrobial resistance epidemiology;    Community;    Colonization;    Household transmission;   

DOI  :  10.1186/s12879-017-2793-y

 received in 2017-08-28, accepted in 2017-10-04,  发布年份 2017

来源: Springer

【 摘 要 】

Background/aimMethicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of MRSA prevalence and transmission.MethodsMRSA-colonized individuals were identified from MRSA admission screening at two tertiary hospitals and recruited together with their household contacts. Participants submitted self-collected nasal, axilla and groin (NAG) swabs by mail for MRSA culture at baseline and monthly thereafter for 6 months. A comparison group of households of MRSA-negative patients provided swab samples at one time point. In a validation sub-study, separate swabs from each site were collected from randomly selected individuals, to compare MRSA detection rates between swab sites, and between samples collected by participants versus those collected by trained research staff. Information on each participant’s demographic information, medical status and medical history, past healthcare facilities usage and contacts, and personal interactions with others were collected using a self-administered questionnaire.Discussion/conclusionUnderstanding the dynamics of MRSA persistence and transmission in the community is crucial to devising and evaluating successful MRSA control strategies. Close contact with MRSA colonized patients may to be important for MRSA persistence in the community; evidence from this study on the extent of community MRSA could inform the development of household- or community-based interventions to reduce MRSA colonization of close contacts and subsequent re-introduction of MRSA into healthcare settings. Analysis of longitudinal data using whole-genome sequencing will yield further information regarding MRSA transmission within households, with significant implications for MRSA infection control outside acute hospital settings.

【 授权许可】

CC BY   
© The Author(s). 2017