Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis?

BMC Musculoskeletal Disorders

Research Article

Peter Oelzner¹  Alexander Pfeil¹  Gunter Wolf¹  Andreas Hansch²  Diane M. Renz³  Joachim Böttcher⁴ 

[1] Department of Internal Medicine III, Jena University Hospital – Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany;Institute of Diagnostic and Interventional Radiology, Heinrich – Braun – Clinic Zwickau, Karl-Kreil-Straße 35, 08060, Zwickau, Germany;Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany;Institute of Diagnostic and Interventional Radiology, SRH Wald-Klinikum Gera GmbH, Straße des Friedens 122, 07548, Gera, Germany;

关键词: Sharp score;    Digital X-ray radiogrammetry;    Rheumatoid arthritis;    Bone mineral density;    Structural integrity;    Radiological progression;   

DOI  :  10.1186/s12891-015-0577-3

 received in 2014-11-11, accepted in 2015-05-08,  发布年份 2015

来源: Springer

【 摘 要 】

IntroductionThe established scoring techniques based on radiographs present limitations in the evaluation of structural integrity due to high effectiveness of innovative therapeutic strategies. The aim of this study was to evaluate the periarticular mineralisation as detected by Digital X-ray Radiogrammetry (DXR) as surrogate marker for structural integrity during the course of rheumatoid arthritis (RA).Methods11 centers throughout Germany contributed data of 94 patients with verified RA. The patients were treated with leflunomide or methotrexate during a mean observation period of 22 months. All patients underwent complete computerized calculations of bone mineral density (BMD) and metacarpal index (MCI) by DXR using digitized hand radiographs. The radiological assessment of disease progression was estimated by the Sharp Score.ResultsThe Sharp Score revealed no significant change during the study period. DXR-BMD revealed minimal decrease of −1.4 % (leflunomide group) versus a higher reduction of −4.3 % (methotrexate group). Regarding DXR-MCI, a reduction of −2.2 % (leflunomide group) and −4.9 % (methotrexate group) was observed.ConclusionQuantitative data of hand bone mass estimated by the presented DXR-technique may be a complementary precise tool in the identification of RA-related radiographic changes and in the assessment of structural integrity.

【 授权许可】

CC BY   
© Pfeil et al. 2015