Whole-heart four-dimensional flow can be acquired with preserved quality without respiratory gating, facilitating clinical use: a head-to-head comparison

BMC Medical Imaging

Research Article

Mikael Kanski¹  Marcus Carlsson¹  Håkan Arheden¹  Katarina Steding-Ehrenborg¹  Einar Heiberg²  Christos Xanthis³  Johannes Töger⁴  Karin Markenroth Bloch⁵ 

[1]Department of Clinical Physiology, Lund University, Lund University Hospital, Lund, Sweden

[2]Department of Clinical Physiology, Lund University, Lund University Hospital, Lund, Sweden

[3]Department of Biomedical Engineering, Faculty of Engineering, Lund University, Lund, Sweden

[4]Center for Mathematics, Faculty of Engineering, Lund University, Lund, Sweden

[5]Department of Clinical Physiology, Lund University, Lund University Hospital, Lund, Sweden

[6]Department of Computer Science and Biomedical informatics, University of Thessaly, Lamia, Greece

[7]Department of Clinical Physiology, Lund University, Lund University Hospital, Lund, Sweden

[8]Department of Numerical Analysis, Center of Mathematical Sciences, Lund University, Lund, Sweden

[9]Philips Healthcare, Lund, Sweden

关键词: Cardiac MRI;    4D flow;    Respiratory gating;    Kinetic energy;    Particle trace;    Vortex ring size;   

DOI  :  10.1186/s12880-015-0061-4

 received in 2014-11-14, accepted in 2015-05-29,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundRespiratory gating is often used in 4D-flow acquisition to reduce motion artifacts. However, gating increases scan time. The aim of this study was to investigate if respiratory gating can be excluded from 4D flow acquisitions without affecting quantitative intracardiac parameters.MethodsEight volunteers underwent CMR at 1.5 T with a 5-channel coil (5ch). Imaging included 2D flow measurements and whole-heart 4D flow with and without respiratory gating (Resp(+), Resp(−)). Stroke volume (SV), particle-trace volumes, kinetic energy, and vortex-ring volume were obtained from 4D flow-data. These parameters were compared between 5ch Resp(+) and 5ch Resp(−). In addition, 20 patients with heart failure were scanned using a 32-channel coil (32ch), and particle-trace volumes were compared to planimetric SV. Paired comparisons were performed using Wilcoxon’s test and correlation analysis using Pearson r. Agreement was assessed as bias ± SD.ResultsStroke volume from 4D flow was lower compared to 2D flow both with and without respiratory gating (5ch Resp(+) 88 ± 18 vs 97 ± 24.0, p = 0.001; 5ch Resp(−) 86 ± 16 vs 97.1 ± 22.7, p < 0.01). There was a good correlation between Resp(+) and Resp(−) for particle-trace derived volumes (R2 = 0.82, 0.2 ± 9.4 ml), mean kinetic energy (R2 = 0.86, 0.07 ± 0.21 mJ), peak kinetic energy (R2 = 0.88, 0.14 ± 0.77 mJ), and vortex-ring volume (R2 = 0.70, −2.5 ± 9.4 ml). Furthermore, good correlation was found between particle-trace volume and planimetric SV in patients for 32ch Resp(−) (R2 = 0.62, −4.2 ± 17.6 ml) and in healthy volunteers for 5ch Resp(+) (R2 = 0.89, −11 ± 7 ml), and 5ch Resp(−) (R2 = 0.93, −7.5 ± 5.4 ml), Average scan duration for Resp(−) was shorter compared to Resp(+) (27 ± 9 min vs 61 ± 19 min, p < 0.05).ConclusionsWhole-heart 4D flow can be acquired with preserved quantitative results without respiratory gating, facilitating clinical use.

【 授权许可】

Unknown   
© Kanski et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.