Radiosensitization in prostate cancer: mechanisms and targets

BMC Urology

Review

Makito Miyake¹  Diego A Palacios²  Charles J Rosser³ 

[1] Cancer Research Institute, MD Anderson Cancer Center Orlando, 32827, Orlando, FL, USA;Section of Urologic Oncology, MD Anderson Cancer Center Orlando, 32806, Orlando, FL, USA;Section of Urologic Oncology, MD Anderson Cancer Center Orlando, 32806, Orlando, FL, USA;Cancer Research Institute, MD Anderson Cancer Center Orlando, 32827, Orlando, FL, USA;

关键词: Cancer;    Prostate;    Radiation;    Radiosensitizer;   

DOI  :  10.1186/1471-2490-13-4

 received in 2012-10-24, accepted in 2012-12-05,  发布年份 2013

来源: Springer

【 摘 要 】

Prostate cancer is the second most commonly diagnosed cancer in American men over the age of 45 years and is the third most common cause of cancer related deaths in American men. In 2012 it is estimated that 241,740 men will be diagnosed with prostate cancer and 28,170 men will succumb to prostate cancer. Currently, radiation therapy is one of the most common definitive treatment options for localized prostate cancer. However, significant number of patients undergoing radiation therapy will develop locally persistent/recurrent tumours. The varying response rates to radiation may be due to 1) tumor microenvironment, 2) tumor stage/grade, 3) modality used to deliver radiation, and 4) dose of radiation. Higher doses of radiation has not always proved to be effective and have been associated with increased morbidity. Compounds designed to enhance the killing effects of radiation, radiosensitizers, have been extensively investigated over the past decade. The development of radiosensitizing agents could improve survival, improve quality of life and reduce costs, thus benefiting both patients and healthcare systems. Herin, we shall review the role and mechanisms of various agents that can sensitize tumours, specifically prostate cancer.

【 授权许可】

Unknown   
© Palacios et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.