Low appendicular muscle mass is correlated with femoral neck bone mineral density loss in postmenopausal women

BMC Musculoskeletal Disorders

Research Article

Jorge Nahas-Neto¹  Eliana AP Nahas¹  Octávio Barbosa-Neto²  Gustavo R da Mota²  Fábio L Orsatti²  Moacir Marocolo²  Cláudio L Orsatti³ 

[1] Department of Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University- UNESP, Brazil;Exercise Biology Laboratory (BioEx), Health Sciences Institute, Triângulo Mineiro Federal University (UFTM), Uberaba-MG, Brazil;Post-graduation Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, São Paulo State University- UNESP, Brazil;

关键词: sarcopenia;    osteoporosis;    menopause;    body composition;    DXA;   

DOI  :  10.1186/1471-2474-12-225

 received in 2011-02-09, accepted in 2011-10-07,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundAfter menopause, rapid bone mass loss occurs in response to hypoestrogenism. Several studies suggest that muscle mass and bone mineral density (BMD) are positively associated in postmenopausal women. Therefore, it may be assumed that postmenopausal low appendicular muscle mass (aMM) can increase BMD loss in a short period of time.ObjectiveThe purpose of this study was to assess relationship of aMM with femoral neck BMD in postmenopausal women.MethodsProspective, controlled clinical Trial including 64 women aged 45-70 years, who had not had their last menstruation for at least one year. Subjects were divided into two groups: low aMM (n = 32), and normal aMM (n-32). Femoral neck BMD and muscle mass were measured by DXA at baseline and after twelve months. Pairwise and independent t tests were used for data analysis.ResultsBaseline weight, BMI and muscle mass (total and appendicular) significantly differ between groups (p < 0.05). After twelve months, femoral neck BMD was significantly lower in the group with low aMM, whereas no significant difference was observed in the group with normal aMM (p < 0.05).ConclusionIn postmenopausal women, low appendicular muscle mass is associated negatively with femoral neck BMD in a short period of time.

【 授权许可】

CC BY   
© Orsatti et al; licensee BioMed Central Ltd. 2011