Low appendicular muscle mass is correlated with femoral neck bone mineral density loss in postmenopausal women

BMC Musculoskeletal Disorders

Gustavo R da Mota¹  Octávio Barbosa-Neto¹  Moacir Marocolo¹  Cláudio L Orsatti²  Jorge Nahas-Neto³  Eliana AP Nahas³  Fábio L Orsatti¹ 

[1] Exercise Biology Laboratory (BioEx), Health Sciences Institute, Triângulo Mineiro Federal University (UFTM), Uberaba-MG, Brazil;Post-graduation Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, São Paulo State University- UNESP, Brazil;Department of Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University- UNESP, Brazil

关键词: DXA;    body composition;    menopause;    osteoporosis;    sarcopenia;   

Others  :  1151905
DOI  :  10.1186/1471-2474-12-225

 received in 2011-02-09, accepted in 2011-10-07,  发布年份 2011

【 摘 要 】

Background

After menopause, rapid bone mass loss occurs in response to hypoestrogenism. Several studies suggest that muscle mass and bone mineral density (BMD) are positively associated in postmenopausal women. Therefore, it may be assumed that postmenopausal low appendicular muscle mass (aMM) can increase BMD loss in a short period of time.

Objective

The purpose of this study was to assess relationship of aMM with femoral neck BMD in postmenopausal women.

Methods

Prospective, controlled clinical Trial including 64 women aged 45-70 years, who had not had their last menstruation for at least one year. Subjects were divided into two groups: low aMM (n = 32), and normal aMM (n-32). Femoral neck BMD and muscle mass were measured by DXA at baseline and after twelve months. Pairwise and independent t tests were used for data analysis.

Results

Baseline weight, BMI and muscle mass (total and appendicular) significantly differ between groups (p < 0.05). After twelve months, femoral neck BMD was significantly lower in the group with low aMM, whereas no significant difference was observed in the group with normal aMM (p < 0.05).

Conclusion

In postmenopausal women, low appendicular muscle mass is associated negatively with femoral neck BMD in a short period of time.

【 授权许可】

   
2011 Orsatti et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Riggs BL, Khosla S, Melton LJ: A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 1998, 13(5):763-73.
• [2]Cummings SR, Melton LJ: Epidemiology and outcomes of osteoporotic fractures. Lancet 2002, 359(9319):1761-7.
• [3]NAMS: Management of osteoporosis in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause 2010, 17(1):25-54. quiz 5-6.
• [4]Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A: Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007, 22(3):465-75.
• [5]Di Monaco M, Vallero F, Di Monaco R, Tappero R: Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture. Arch Gerontol Geriatr 2010.
• [6]Gentil P, Lima RM, Jaco de Oliveira R, Pereira RW, Reis VM: Association between femoral neck bone mineral density and lower limb fat-free mass in postmenopausal women. J Clin Densitom 2007, 10(2):174-8.
• [7]Genaro PS, Pereira GA, Pinheiro MM, Szejnfeld VL, Martini LA: Influence of body composition on bone mass in postmenopausal osteoporotic women. Arch Gerontol Geriatr 2010.
• [8]Nguyen TV, Sambrook PN, Eisman JA: Bone loss, physical activity, and weight change in elderly women: the Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res 1998, 13(9):1458-67.
• [9]Sirola J, Kroger H, Honkanen R, Sandini L, Tuppurainen M, Jurvelin JS, et al.: Risk factors associated with peri- and postmenopausal bone loss: does HRT prevent weight loss-related bone loss? Osteoporos Int 2003, 14(1):27-33.
• [10]Aloia JF, McGowan DM, Vaswani AN, Ross P, Cohn SH: Relationship of menopause to skeletal and muscle mass. Am J Clin Nutr 1991, 53(6):1378-83.
• [11]Douchi T, Yamamoto S, Yoshimitsu N, Andoh T, Matsuo T, Nagata Y: Relative contribution of aging and menopause to changes in lean and fat mass in segmental regions. Maturitas 2002, 42(4):301-6.
• [12]Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al.: Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010, 39(4):412-23.
• [13]Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, et al.: Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998, 147(8):755-63.
• [14]Karasik D, Kiel DP: Evidence for pleiotropic factors in genetics of the musculoskeletal system. Bone 2010, 46(5):1226-37.
• [15]Sievanen H: Hormonal influences on the muscle-bone feedback system: a perspective. J Musculoskelet Neuronal Interact 2005, 5(3):255-61.
• [16]Orsatti FL, Nahas EA, Nahas-Neto J, Maesta N, Orsatti CL, Fernandes CE: Effects of resistance training and soy isoflavone on body composition in postmenopausal women. Obstet Gynecol Int 2010, 2010:156037.
• [17]Kerr DA, Papalia S, Morton A, Dick I, Dhaliwal S, Prince RL: Bone mass in young women is dependent on lean body mass. J Clin Densitom 2007, 10(3):319-26.
• [18]Heymsfield SB, Smith R, Aulet M, Bensen B, Lichtman S, Wang J, et al.: Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 1990, 52(2):214-8.
• [19]Visser M, Fuerst T, Lang T, Salamone L, Harris TB: Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol 1999, 87(4):1513-20.
• [20]Chen Z, Wang Z, Lohman T, Heymsfield SB, Outwater E, Nicholas JS, et al.: Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women. J Nutr 2007, 137(12):2775-80.
• [21]Cui LH, Shin MH, Kweon SS, Park KS, Lee YH, Chung EK, et al.: Relative contribution of body composition to bone mineral density at different sites in men and women of South Korea. J Bone Miner Metab 2007, 25(3):165-71.
• [22]Robling AG: Is bone's response to mechanical signals dominated by muscle forces? Med Sci Sports Exerc 2009, 41(11):2044-9.
• [23]Kemmler W, Lauber D, Weineck J, Hensen J, Kalender W, Engelke K: Benefits of 2 years of intense exercise on bone density, physical fitness, and blood lipids in early postmenopausal osteopenic women: results of the Erlangen Fitness Osteoporosis Prevention Study (EFOPS). Arch Intern Med 2004, 164(10):1084-91.
• [24]Orsatti FL, Nahas EA, Maesta N, Nahas-Neto J, Burini RC: Plasma hormones, muscle mass and strength in resistance-trained postmenopausal women. Maturitas 2008, 59(4):394-404.
• [25]Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR: American College of Sports Medicine Position Stand: physical activity and bone health. Med Sci Sports Exerc 2004, 36(11):1985-96.
• [26]Macdonald HM, New SA, Campbell MK, Reid DM: Influence of weight and weight change on bone loss in perimenopausal and early postmenopausal Scottish women. Osteoporos Int 2005, 16(2):163-71.
• [27]Sirola J, Rikkonen T, Tuppurainen M, Honkanen R, Jurvelin JS, Kroger H: Maintenance of muscle strength may counteract weight-loss-related postmenopausal bone loss--a population-based approach. Osteoporos Int 2006, 17(5):775-82.
• [28]Blain H, Vuillemin A, Teissier A, Hanesse B, Guillemin F, Jeandel C: Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over. Gerontology 2001, 47(4):207-12.
• [29]Pfeilschifter J, Koditz R, Pfohl M, Schatz H: Changes in proinflammatory cytokine activity after menopause. Endocr Rev 2002, 23(1):90-119.
• [30]Nordstrom A, Gerdhem P, Brandstrom H, Stiger F, Lerner UH, Lorentzon M, et al.: Interleukin-6 promoter polymorphism is associated with bone quality assessed by calcaneus ultrasound and previous fractures in a cohort of 75-year-old women. Osteoporos Int 2004, 15(10):820-6.
• [31]Kwan Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y: IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 2004, 15(1):49-60.
• [32]Gnudi S, Sitta E, Fiumi N: Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007, 25(5):326-32.
• [33]Judex S, Carlson KJ: Is bone's response to mechanical signals dominated by gravitational loading? Med Sci Sports Exerc 2009, 41(11):2037-43.
• [34]Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, et al.: Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA 2004, 101(9):3258-63.
• [35]Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL: Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 2005, 289(5):E735-45.