Effects of infant weight gain on subsequent allergic outcomes in the first 3 years of life

BMC Pediatrics

Research Article

Yiong Huak Chan¹  Mya Thway Tint²  Michael S Kramer³  Fabian Yap⁴  Anne Goh⁵  Oon Hoe Teoh⁶  Bee Wah Lee⁷  Lynette Pei-Chi Shek⁸  Hugo Van Bever⁸  Keith M Godfrey⁹  Seang-Mei Saw^1,10  Evelyn Xiu-Ling Loo^1,11  Shu-E Soh^1,11  Yap-Seng Chong^1,12  Izzuddin Bin Mohd Aris^1,13  Yung Seng Lee^1,14  Peter Gluckman^1,15 

[1] Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Department of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University Faculty of Medicine, H3A 1A2, Montréal, QC, Canada;Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, 229899, Singapore, Singapore;Department of Paediatrics, Allergy service, KK Women’s and Children’s Hospital, 229899, Singapore, Singapore;Department of Paediatrics, Respiratory Service Medicine, KK Women’s and Children’s Hospital, 229899, Singapore, Singapore;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, 119228, Singapore, Singapore;NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, SO16 6YD, Southampton, UK;Medical Research Council Lifecourse Epidemiology Unit, SO16 6YD, Southampton, UK;Saw Swee Hock School of Public Health, National University of Singapore, 117549, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 117609, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 117609, Singapore, Singapore;Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 117609, Singapore, Singapore;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 117609, Singapore, Singapore;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Division of Endocrinology and Diabetes, Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, 119074, Singapore, Singapore;Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 117609, Singapore, Singapore;Liggins Institute, University of Auckland, 1023, Auckland, New Zealand;

关键词: Obesity;    Allergy;    Allergen sensitization;    Birth cohort;    Early childhood;   

DOI  :  10.1186/s12887-017-0890-0

 received in 2016-11-02, accepted in 2017-05-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe association between early weight gain and later allergic outcomes has not been well studied. We examined the relation between weight gain and the subsequent development of allergic outcomes in the first 36 months of life in a Singapore birth cohort.MethodsIn repeated visits in the first 15 months, we measured infant weight and administered questionnaires ascertaining allergic outcomes. At ages 18 and 36 months, we administered skin prick tests (SPTs) to inhalant and food allergens.ResultsAt 18 months, 13.5% had a positive SPT, 3.5% had wheeze and a positive SPT, 3.9% had rhinitis and a positive SPT, and 6.1% had eczema and a positive SPT. Higher weight gain from 6 to 9 months, 9 to 12 months and 12 to 15 months were independently associated with a reduced risk of developing a positive SPT at 18 months (p-trend ≤0.03). At 36 months, 23.5% had a positive SPT, 11.9% had wheeze and a positive SPT, 12.2% rhinitis and a positive SPT, and 11.5% eczema and a positive SPT. Higher weight gain from 12 to 15 months was associated with a reduced risk of developing a positive SPT at 36 months (p-trend <0.01). No significant associations were observed between weight gain in any period and wheeze, rhinitis or eczema combined with a positive SPT at 18 or 36 months.ConclusionHigher weight gain in the first 15 months of life was associated with a reduced risk of allergen sensitization, but not with combinations of allergic symptoms.Trial registrationNCT01174875 Registered 1 July 2010, retrospectively registered.

【 授权许可】

CC BY   
© The Author(s). 2017