A novel strain of cynomolgus macaque cytomegalovirus: implications for host-virus co-evolution

BMC Genomics

Research Article

Ben J. Evans¹  Michael Brudno²  Misko Dzamba²  Justen N. Hoffman Russell³  Angie K. Marsh³  Kelly S. MacDonald⁴  David O. Willer⁵  Joseph M. Antony⁵  Jacqueline K. Chan⁵  Aruna P. N. Ambagala⁶  Paul Sandstrom⁷  Richard Pilon⁷  Jocelyn Fournier⁸ 

[1] Biology Department, McMaster University, Life Sciences Building, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada;Department of Computer Science, University of Toronto, M5S 1A8, Toronto, ON, Canada;Department of Immunology, University of Toronto, M5S 1A8, Toronto, ON, Canada;Department of Immunology, University of Toronto, M5S 1A8, Toronto, ON, Canada;Department of Medicine, University of Toronto, M5S 1A8, Toronto, ON, Canada;Department of Microbiology, Mount Sinai Hospital, M5G 1X5, Toronto, ON, Canada;Section of Infectious Diseases, Department of Internal Medicine, University of Manitoba, 745 Bannatyne Ave, R3E 0J9, Winnipeg, MB, Canada;Present Address: University of Manitoba, Basic Medical Sciences Building, Room 501, 745 Bannatyne Ave., R3E 0J9, Winnipeg, MB, Canada;Department of Medicine, University of Toronto, M5S 1A8, Toronto, ON, Canada;Department of Microbiology, Mount Sinai Hospital, M5G 1X5, Toronto, ON, Canada;Department of Medicine, University of Toronto, M5S 1A8, Toronto, ON, Canada;Department of Microbiology, Mount Sinai Hospital, M5G 1X5, Toronto, ON, Canada;Present Address: Canadian Science Centre for Human and Animal Health, National Centre for Foreign Animal Disease, 1015 Arlington Street, R3E 3M4, Winnipeg, MB, Canada;National HIV & Retrovirology Laboratories, Public Health Agency of Canada, K1A 0K9, Ottawa, ON, Canada;Scientific Services Division, Health Products & Food Branch, Health Canada, K1A 0L2, Ottawa, ON, Canada;

关键词: Cynomolgus macaque;    Cytomegalovirus;    Phylogenetics;    Co-speciation;    Co-evolution;   

DOI  :  10.1186/s12864-016-2588-3

 received in 2015-10-09, accepted in 2016-03-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCytomegaloviruses belong to a large, ancient, genus of DNA viruses comprised of a wide array of species-specific strains that occur in diverse array of hosts.MethodsIn this study we sequenced the ~217 Kb genome of a cytomegalovirus isolated from a Mauritius cynomolgus macaque, CyCMV Mauritius, and compared it to previously sequenced cytomegaloviruses from a cynomolgus macaque of Filipino origin (CyCMV Ottawa) and two from Indian rhesus macaques (RhCMV 180.92 and RhCMV 68–1).ResultsThough more closely related to CyCMV Ottawa, CyCMV Mauritius is less genetically distant from both RhCMV strains than is CyCMV Ottawa. Several individual genes, including homologues of CMV genes RL11B, UL123, UL83b, UL84 and a homologue of mammalian COX-2, show a closer relationship between homologues of CyCMV Mauritius and the RhCMVs than between homologues of CyCMV Mauritius and CyCMV Ottawa. A broader phylogenetic analysis of 12 CMV strains from eight species recovers evolutionary relationships among viral strains that mirror those amongst the host species, further demonstrating co-evolution of host and virus.ConclusionsPhylogenetic analyses of rhesus and cynomolgus macaque CMV genome sequences demonstrate co-speciation of the virus and host.

【 授权许可】

CC BY   
© Russell et al. 2016