Soshiho-tang water extract inhibits ovalbumin-induced airway inflammation via the regulation of heme oxygenase-1

BMC Complementary and Alternative Medicine

Research Article

Sang Kyum Kim¹  In-Sik Shin²  Hyeun-Kyoo Shin³  Mee-Young Lee³  Woo-Young Jeon⁴ 

[1] College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea;College of Veterinary Medicine, Chonnam National University, 77 Yongbong-ro, Buk-gu, 500-757, Gwangju, Republic of Korea;K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, 305-811, Daejeon, Republic of Korea;K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, 305-811, Daejeon, Republic of Korea;College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 305-764, Daejeon, Republic of Korea;

关键词: Soshiho-tang;    Asthma;    Eosinophils;    Th2-type cytokines;    IgE;    Heme oxygenase-1;   

DOI  :  10.1186/s12906-015-0857-3

 received in 2015-06-18, accepted in 2015-09-11,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSoshiho-tang, known as Xio-hai-Hu-Tang in Chinese and Sho-Saiko-to in Japanese, has been widely used as a therapeutic agent. Its pharmacological effects include anti-inflammatory, antioxidant, antihepatic fibrosis, antitumor and immunomodulating activities. However, little is known regarding its effects on allergic asthma. Therefore, the aim of the present study was to investigate whether the Soshiho-tang water extract (SSTW) has antiasthmatic effects on airway inflammation in an ovalbumin (OVA)-induced mouse model.MethodsBALB/c mice were used as a model of asthma after induction by sensitization and challenge with OVA. We measured change in eosinophils, other inflammatory cells, and T helper 2 (Th2)-type cytokines, such as interleukin (IL)-4, IL-5, IL-13, IL-17, IL-33, and chemokine (eotaxin) in bronchoalveolar lavage fluid (BALF), presence of total and OVA-specific immunoglobulin (Ig)E in plasma, and expression of mucus production and heme oxygenase (HO)-1 protein in lung tissue.ResultsOur results show that SSTW had a suppressive effect on eosinophil influx into BALF and decreased the levels of Th2-type cytokines. Moreover, SSTW exhibited a marked decrease in mucus hypersecretion, total and OVA-specific IgE levels, and significantly induced HO-1 protein expression.ConclusionsThese results suggest that SSTW may be used as a valuable therapeutic agent for treating various inflammatory diseases including allergic asthma.

【 授权许可】

CC BY   
© Jeon et al. 2015