A systematic review of reported reassortant viral lineages of influenza A

BMC Infectious Diseases

Research Article

Amy Pinsent¹  Neil M. Ferguson¹  Steven Riley¹  Christophe Fraser¹ 

[1] Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analyses and Modelling, School of Public Health, Imperial College London, London, UK;

关键词: Influenza;    Reassortment;    Reassortant;    Evolution;    Genomic data;    Reporting;    Pandemic;   

DOI  :  10.1186/s12879-015-1298-9

 received in 2015-07-06, accepted in 2015-11-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMost previous evolutionary studies of influenza A have focussed on genetic drift, or reassortment of specific gene segments, hosts or subtypes. We conducted a systematic literature review to identify reported claimed reassortant influenza A lineages with genomic data available in GenBank, to obtain 646 unique first-report isolates out of a possible 20,781 open-access genomes.ResultsAfter adjusting for correlations, only: swine as host, China, Europe, Japan and years between 1997 and 2002; remained as significant risk factors for the reporting of reassortant viral lineages. For swine H1, more reassortants were observed in the North American H1 clade compared with the Eurasian avian-like H1N1 clade. Conversely, for avian H5 isolates, a higher number of reported reassortants were observed in the European H5N2/H3N2 clade compared with the H5N2 North American clade.ConclusionsDespite unavoidable biases (publication, database choice and upload propensity) these results synthesize a large majority of the current literature on novel reported influenza A reassortants and are a potentially useful prerequisite to inform further algorithmic studies.

【 授权许可】

CC BY   
© Pinsent et al. 2015