Cross-sectional associations between prevalent vertebral fracture and pulmonary function in the sixth Tromsø study

BMC Geriatrics

Research Article

Svanhild Waterloo¹  Marte R Thomassen²  Bente Morseth³  Nina Emaus⁴  Hasse Melbye⁵  Marijke J Risberg⁶ 

[1] Department of Community Medicine, University of Tromsø, Tromsø, Norway;Department of Community Medicine, University of Tromsø, Tromsø, Norway;Department of Occupational and Environmental Medicine, University Hospital of North Norway, Tromsø, Norway;Department of Community Medicine, University of Tromsø, Tromsø, Norway;Regional Centre for Sport, Exercise and Health, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway;Department of Health and Care Sciences, University of Tromsø, Tromsø, Norway;General Practice Research Unit, Department of Community Medicine, University of Tromsø, Tromsø, Norway;University Hospital of North Norway, Tromsø, Norway;

关键词: Vertebral fractures;    Pulmonary function;    Lung function;    Population study;    Epidemiology;    Elderly;   

DOI  :  10.1186/1471-2318-13-116

 received in 2013-03-14, accepted in 2013-10-28,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPersons with vertebral fracture may have reduced pulmonary function, but this association has not been much studied. The aim of this cross-sectional study was therefore to examine the relationship between vertebral fracture and pulmonary function in a general, elderly population.MethodsVertebral morphometry was used for vertebral fracture assessment in 2132 elderly men (n = 892) and women (n = 1240) aged 55 to 87 years in the population-based Tromsø Study 2007–08. Pulmonary function was examined by spirometry. Pulmonary function was expressed as FVC% predicted, FEV1% predicted, and FEV1/FVC% predicted values, adjusted FVC, FEV1, and FEV1/FVC, and obstructive and restrictive ventilatory impairment. Vertebral fracture was classified according to appearance, number, severity, and location of fractures. Associations were analyzed using general linear and logistic models.ResultsFVC% predicted and FEV1% predicted values were not associated with vertebral fracture (P > 0.05), whereas FEV1/FVC% predicted ratio was associated with both prevalent fracture, number of fractures, severity of fractures, and fracture site in men (P < 0.05), but not in women. When FVC, FEV1, and FEV1/FVC values were adjusted for multiple covariates, we found no significant association with vertebral fracture. Obstructive and restrictive ventilatory impairment was not associated with prevalent vertebral fracture.ConclusionsIn conclusion, this study did not confirm any clinically relevant associations between prevalent vertebral fracture and ventilatory impairment in elderly individuals.

【 授权许可】

CC BY   
© Morseth et al.; licensee BioMed Central Ltd. 2013