Cross-sectional associations between prevalent vertebral fracture and pulmonary function in the sixth Tromsø study

BMC Geriatrics

Nina Emaus¹  Marijke J Risberg³  Marte R Thomassen⁵  Svanhild Waterloo²  Hasse Melbye⁴  Bente Morseth⁶ 

[1] Department of Health and Care Sciences, University of Tromsø, Tromsø, Norway;Department of Community Medicine, University of Tromsø, Tromsø, Norway;University Hospital of North Norway, Tromsø, Norway;General Practice Research Unit, Department of Community Medicine, University of Tromsø, Tromsø, Norway;Department of Occupational and Environmental Medicine, University Hospital of North Norway, Tromsø, Norway;Regional Centre for Sport, Exercise and Health, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

关键词: Elderly;    Epidemiology;    Population study;    Lung function;    Pulmonary function;    Vertebral fractures;   

Others  :  856686
DOI  :  10.1186/1471-2318-13-116

 received in 2013-03-14, accepted in 2013-10-28,  发布年份 2013

【 摘 要 】

Background

Persons with vertebral fracture may have reduced pulmonary function, but this association has not been much studied. The aim of this cross-sectional study was therefore to examine the relationship between vertebral fracture and pulmonary function in a general, elderly population.

Methods

Vertebral morphometry was used for vertebral fracture assessment in 2132 elderly men (n = 892) and women (n = 1240) aged 55 to 87 years in the population-based Tromsø Study 2007–08. Pulmonary function was examined by spirometry. Pulmonary function was expressed as FVC% predicted, FEV₁% predicted, and FEV₁/FVC% predicted values, adjusted FVC, FEV₁, and FEV₁/FVC, and obstructive and restrictive ventilatory impairment. Vertebral fracture was classified according to appearance, number, severity, and location of fractures. Associations were analyzed using general linear and logistic models.

Results

FVC% predicted and FEV₁% predicted values were not associated with vertebral fracture (P > 0.05), whereas FEV₁/FVC% predicted ratio was associated with both prevalent fracture, number of fractures, severity of fractures, and fracture site in men (P < 0.05), but not in women. When FVC, FEV₁, and FEV₁/FVC values were adjusted for multiple covariates, we found no significant association with vertebral fracture. Obstructive and restrictive ventilatory impairment was not associated with prevalent vertebral fracture.

Conclusions

In conclusion, this study did not confirm any clinically relevant associations between prevalent vertebral fracture and ventilatory impairment in elderly individuals.

【 授权许可】

   
2013 Morseth et al.; licensee BioMed Central Ltd.

【 图 表 】

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