Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico

BMC Complementary and Alternative Medicine

Research Article

Gerónimo Maldonado-Martínez¹  Luis A. Cubano²  Alexandra Aguilar-Perez³  Michelle M. Martínez-Montemayor³  Lorelein Morales-Santiago⁴  Natalie Rivera-Ortiz⁴  Jannette Gavillán-Suárez⁵  Wanda Figueroa-Cuilan⁶  Karla Rodríguez-Tirado⁷ 

[1] Data Management & Statistical Research Support Unit, Universidad Central del Caribe-School of Medicine, P.O. Box 60327, 00960-6032, Bayamón, Puerto Rico;Department of Anatomy and Cell Biology, Universidad Central del Caribe-School of Medicine, P.O. Box 60327, 00960-6032, Bayamón, Puerto Rico;Department of Biochemistry, Universidad Central del Caribe-School of Medicine, P.O. Box 60327, 00960-6032, Bayamón, Puerto Rico;Department of Chemistry, University of Puerto Rico at Cayey, PO Box 372230, 00737-2230, Cayey, Puerto Rico;Institute of Interdisciplinary Research, University of Puerto Rico at Cayey, PO Box 372230, 00737-2230, Cayey, Puerto Rico;Department of Chemistry, University of Puerto Rico at Cayey, PO Box 372230, 00737-2230, Cayey, Puerto Rico;Present address: University of Missouri-Columbia, Division of Biological Sciences, 110 Tucker Hall, 65211-7400, Columbia, MO, USA;Present address: University of Puerto Rico Medical Sciences Campus, PO Box 365067, 00936-5067, San Juan, Puerto Rico;

关键词: Diabetes adjuvants;    db/db;    Chemical profile;    Syzygium jambos;    Tapeinochilus ananassae;    Costus speciosus;   

DOI  :  10.1186/s12906-015-0772-7

 received in 2015-02-06, accepted in 2015-07-08,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Puerto Rico has the highest rate of Type 2 diabetes within all the states and territories of the United States, and Puerto Ricans commonly use plants as diabetes adjuvants, it is important to study the plants’ physiological effects, and identify their bioactive compounds to understand their role in modulation of blood glucose levels. We present the phytochemical profiles and hypoglycemic effects of Tapeinochilus ananassae, Costus speciosus and Syzygium jambos.MethodsPhytochemicals in methanolic and aqueous extracts were analyzed by thin layer chromatography (TLC). Alkaloids (Bromocresol green, λ = 470 nm), flavonoids (AlCl3, λ = 415 nm), saponins (DNS, λ = 760 nm), tannins (FeCl3/K4Fe(CN)6, λ = 395 nm) and phenolics (Folin-Ciocalteau, λ = 765 nm) were quantified. Male C57BLKS/J (db/db) and C57BL/J (ob/ob) genetically obese mice were orally gavaged with aqueous extracts of lyophilized plant decoctions for 10wks.ResultsOur results show that T. ananassae had significantly greater amounts of flavonoids and tannins, while S. jambos showed the greatest concentration of phenolics and C. speciosus exhibited higher amounts of alkaloids. C57BLKS/J db/db treated with plant extracts show better glucose modulation when the extracts are administered in complement with an insulin injection. Finally, C57BL/J ob/ob mice on T. ananassae and S. jambos treatments show better blood glucose modulation over time.ConclusionThese results document for the first time the chemical profile of T. ananassae and provide evidence for a potential anti-diabetic efficacy of T. ananassae and S. jambos.

【 授权许可】

Unknown   
© Gavillán-Suárez et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.