The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training

BMC Geriatrics

Research Article

Mikel Izquierdo¹  António M Monteiro²  José C Leitão³  António J Silva³  Ana Pereira³  Aldo M Costa⁴  Estela Bastos⁵  Mário C Marques⁶ 

[1] Department of Health Sciences, Public University of Navarra, Campus of Tudela, Av. de Tarazona s/n, 31500, Tudela, Navarra, Spain;Department of Sport Sciences, Polytechnic Institute of Bragança, Bragança, Portugal;Department of Sport Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;Research Centre in Sports, Health and Human Development, Vila Real, Portugal;Department of Sports Sciences, University of Beira Interior, Covilhã, Portugal;Research Centre in Sports, Health and Human Development, Vila Real, Portugal;CICS-UBI, Health Sciences Research Center, Covilhã, Portugal;Institute for Biotechnology and Bioengineering, Centre for Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;Research Centre in Sports, Health and Human Development, Vila Real, Portugal;Department of Sports Sciences, University of Beira Interior, Covilhã, Portugal;

关键词: Resistance training;    Angiotensin converting-enzyme;    Alpha-Actinin-3;    Women;    Lower mobility;   

DOI  :  10.1186/1471-2318-13-131

 received in 2013-04-11, accepted in 2013-12-03,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundWe studied the influence of the ACE I/D and ACTN3 R577X polymorphisms (single or combined) on lower-extremity function in older women in response to high-speed power training.MethodsOne hundred and thirty-nine healthy older Caucasian women participated in this study (age: 65.5 ± 8.2 years, body mass: 67.0 ± 10.0 kg and height: 1.57 ± 0.06 m). Walking speed (S10) performance and functional capacity assessed by the “get-up and go” (GUG) mobility test were measured at baseline (T1) and after a consecutive 12-week period of high-speed power training (40-75% of one repetition maximum in arm and leg extensor exercises; 3 sets 4–12 reps, and two power exercises for upper and lower extremity). Genomic DNA was extracted from blood samples, and genotyping analyses were performed by PCR methods. Genotype distributions between groups were compared by Chi-Square test and the gains in physical performance were analyzed by two-way, repeated-measures ANOVA.ResultsThere were no significant differences between genotype groups in men or women for adjusted baseline phenotypes (P > 0.05). ACE I/D and ACTN3 polymorphisms showed a significant interaction genotype-training only in S10 (P = 0.012 and P = 0.044, respectively) and not in the GUG test (P = 0.311 and P = 0.477, respectively). Analyses of the combined effects between genotypes showed no other significant differences in all phenotypes (P < 0.05) at baseline. However, in response to high-speed power training, a significant interaction on walking speed (P = 0.048) was observed between the “power” (ACTN3 RR + RX & ACE DD) versus “non-power” muscularity-oriented genotypes (ACTN3 XX & ACE II + ID)].ConclusionsThus, ACE I/D and ACTN3 R577X polymorphisms are likely candidates in the modulation of exercise-related gait speed phenotype in older women but not a significant influence in mobility traits.

【 授权许可】

Unknown   
© Pereira et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.