Optical and material analysis of opacified hydrophilic intraocular lenses after explantation: a laboratory study

BMC Ophthalmology

Research Article

Gerd U. Auffarth¹  Alexander Scheuerle¹  Ramin Khoramnia¹  Tamer Tandogan¹  Chul Young Choi²  Philipp Hugger³  Martin Wenzel⁴ 

[1] David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany;David J Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany;Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyeong-dong, Jongno-gu, Seoul, South Korea;Eye Clinic Esslingen, Esslingen, Germany, Augen-Praxis-Klinik-Esslingen Adlerstraße 6, 73728, Esslingen, Germany;Eye Clinic Petrisberg, Trier, Germany, Max-Planck-Straße 16, 54296, Trier, Germany;

关键词: Spectroscopy;    Electron microscopy;    IOL;    Opacification;    Calcification;    MTF;    USAF target;    Optical bench;    IOL metrology;   

DOI  :  10.1186/s12886-015-0149-1

 received in 2015-06-30, accepted in 2015-10-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe opacification of hydrophilic intraocular lenses (IOLs) is a very rare complication in terms of absolute numbers. We report on the analyses of opacified Euromaxx ALI313Y and ALI313 IOLs (Argonoptics, Germany) using light and scanning electron microscopy, X-ray spectroscopy and optical bench analysis.MethodsOpacified Euromaxx ALI313Y and ALI313 IOLs were explanted after patients presented with a decrease in visual acuity. The explants were sent to our laboratory and examined using light and scanning electron microscopy. The composition of the deposits was analysed using X-ray spectroscopy. The optical quality of the intraocular lens (IOL) was assessed using the OptiSpheric IOL PRO optical bench (Trioptics GmbH Wedel, Germany). Modulation transfer function (MTF) was measured at all spatial frequencies and United States Air Force (USAF) 1951 resolution target pictures were documented.ResultsMacroscopically, the entire optic was opacified in all IOLs. Light and scanning electron microscopy revealed numerous fine, granular, crystalline-like deposits, which were always distributed in a line parallel to the anterior and posterior surfaces of the IOLs. X-ray spectroscopy could prove the deposits consisted of Calcium and Phosphate. Measurements in the optical bench showed deterioration of MTF values at all spatial frequencies and the USAF target pictures demonstrated a significant reduction of brightness as well as resolution with the opacified IOLs.ConclusionsThe calcification of hydrophilic IOLs only occurs rarely. The exact chemical composition of the deposits can be assessed by means of X-ray spectroscopy. Optical quality analysis of the explanted Euromaxx ALI313Y and ALI313 IOLs showed significant reduction of MTF values, which was confirmed by USAF target pictures.

【 授权许可】

CC BY   
© Tandogan et al. 2015