Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population

BMC Cardiovascular Disorders

Research Article

Geu-Ru Hong¹  Sanghoon Shin¹  Namsik Chung¹  In-Jeong Cho¹  Chi-Young Shim¹  Ki-Bum Won²  Hyuk-Jae Chang³  Byung-Wook Choi⁴  Young Jin Kim⁴  Jimin Sung⁵ 

[1] Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea;Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea;Division of Cardiology, St. Luke’s International Hospital, Tokyo, Japan;Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea;Severance Biomedical Science Institute, Seoul, South Korea;Yonsei Cardiovascular Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea;Division of Radiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea;Graduate School of Health and Welfare CHA University, Seongnam, South Korea;

关键词: Metabolic syndrome;    Diabetes;    Coronary artery disease;    Coronary computed tomographic angiography;   

DOI  :  10.1186/1471-2261-14-105

 received in 2014-03-17, accepted in 2014-08-13,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.MethodsWe evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.ResultsThe prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.ConclusionsMetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.

【 授权许可】

Unknown   
© Won et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.