Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population

BMC Cardiovascular Disorders

Namsik Chung⁵  Byung-Wook Choi¹  Young Jin Kim¹  Geu-Ru Hong⁵  Chi-Young Shim⁵  In-Jeong Cho⁵  Sanghoon Shin⁵  Jimin Sung³  Hyuk-Jae Chang⁴  Ki-Bum Won² 

[1] Division of Radiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Republic of Korea;Division of Cardiology, St. Luke’s International Hospital, Tokyo, Japan;Graduate School of Health and Welfare CHA University, Seongnam, Republic of Korea;Yonsei Cardiovascular Center, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 Republic of Korea;Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Republic of Korea

关键词: Coronary computed tomographic angiography;    Coronary artery disease;    Diabetes;    Metabolic syndrome;   

Others  :  1088467
DOI  :  10.1186/1471-2261-14-105

 received in 2014-03-17, accepted in 2014-08-13,  发布年份 2014

【 摘 要 】

Background

Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.

Methods

We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.

Results

The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.

Conclusions

MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.

【 授权许可】

   
2014 Won et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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