Evaluation of antihyperglycemic and antinociceptive activity of Xanthium indicum stem extract in Swiss albino mice

BMC Complementary and Alternative Medicine

Research Article

Md Ezazul Haque¹  Shahnaz Rahman¹  Rownak Jahan¹  Mohammed Rahmatullah² 

[1] Department of Biotechnology and Genetic Engineering, University of Development Alternative, 1209, Dhanmondi, Dhaka, Bangladesh;Faculty of Life Sciences, University of Development Alternative, House No. 78, Road No. 11A (new), 1209, Dhanmondi, Dhaka, Bangladesh;

关键词: Antihyperglycemic;    Xanthium indicum;    Glucose tolerance;    Antinociceptive;    Asteraceae;   

DOI  :  10.1186/1472-6882-13-296

 received in 2013-08-15, accepted in 2013-10-29,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundXanthium indicum stem is used in folk medicine of Bangladesh to control sugar in diabetic patients and to alleviate pain. The objective of the study was to evaluate antihyperglycemic and antinociceptive activity of methanolic extract of Xanthium indicum stems (XISE) in mice.MethodsAntihyperglycemic activity was measured by oral glucose tolerance tests in glucose-loaded Swiss albino mice. Antinociceptive activity was determined by observed decreases in abdominal constrictions in acetic acid-induced gastric pain model in mice.ResultsThe methanol extract of stems showed dose-dependent and statistically significant antihyperglycemic activity at doses of 50, 100, 200 and 400 mg per kg body weight (p values, respectively, < than 0.01, 0.01, 0.005, and 0.01). Highest reduction in blood glucose level (31.2%) was observed with the highest dose (400 mg) of the extract. A standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels by 46.2%, when administered at a dose of 10 mg per kg body weight. In antinociceptive activity tests, the extract when administered at the afore-mentioned four doses, reduced the number of abdominal constrictions in mice, respectively, by 41.7, 50.0, 54.2, and 61.0%. In comparison, a standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight, reduced the number of abdominal constrictions by 37.5%.ConclusionThe experimental results obtained in the present study validate the use of X. indicum stems in folk medicines of Bangladesh to lower blood sugar in diabetic patients and to alleviate pain.

【 授权许可】

Unknown   
© Haque et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.