Altered fractional amplitude of low frequency fluctuation associated with cognitive dysfunction in first-episode drug-naïve major depressive disorder patients

BMC Psychiatry

Research Article

Jian Weng¹  Liang Yu²  Manli Huang³  Ning Wei³  Weihua Zhou³  Jinwen Huang³  Yi Xu³  Shaohua Hu³  Jianbo Hu³  Shaojia Lu³  Peng Zhang⁴  Lingjiang Li⁵ 

[1] Bio-X Lab, Department of Physics, Zhejiang University, Hangzhou, Zhejiang, China;Department of Anesthesiology and Pain, Hang Zhou First People’s Hospital, Hangzhou, Zhejiang, China;Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, No. 79, Qingchun Road, 310003, Hangzhou, Zhejiang, China;Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, No. 79, Qingchun Road, 310003, Hangzhou, Zhejiang, China;Mental Health Centre, Xiaoshan Hospital of Zhejiang Province, Hangzhou, Zhejiang, China;Mental Health Institute, The Second Xiangya Hospital, Central South University, Key Laboratory of Psychiatry and Mental Health of Hunan Province, National Technology Institute of Psychiatry and Mental Health, Changsha, Hunan, China;

关键词: Major depressive disorder;    Cognitive function;    Fractional amplitude of low frequency fluctuation (fALFF);   

DOI  :  10.1186/s12888-016-1190-1

 received in 2016-01-14, accepted in 2016-12-31,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPrevious studies have demonstrated that abnormities of both resting-state brain activity and cognitive dysfunction are frequently observed in patients with major depressive disorder (MDD). However, the underlying relationship between these two aspects is less investigated. In this context, the aim of the present study was to investigate the association between cognitive dysfunction and altered resting-state brain function in first-episode drug-naïve MDD patients.MethodsTwenty-five drug-naïve MDD patients and twenty-six age-, sex-, and education-matched normal controls were recruited in this study. Cognitive function was evaluated by using a series of validated test procedures. The resting-state functional magnetic resonance imaging data were obtained on a Philips 3.0 Tesla scanner and analysed using the fractional amplitude of low frequency fluctuation (fALFF) method. Correlations of fALFF values with cognitive dysfunction were further analysed.ResultsCompared with healthy controls, MDD patients showed significantly fewer completed categories in the Wisconsin Card Sorting Test (WCST) and decreased scores in the first and second subtests of the Continuous Performance Test (CPT). However, the two groups did not differ in their performance on the Stroop Colour Word Test and Trail-making Test. MDD patients exhibited significantly decreased fALFF values in the left superior frontal gyrus (SFG), left middle frontal gyrus, and left inferior frontal gyrus, as well as increased fALFF values in the left inferior temporal gyrus (ITG), bilateral parahippocampal gyrus, and the right caudate. Finally, the correlation analyses revealed that fALFF values in the left SFG and left ITG were associated with the number of WSCT completed categories and scores on the second subtest of the CPT in MDD, respectively.ConclusionsThe present findings suggest that there is little evidence of an association between regional abnormalities in resting-state brain function and cognitive deficits in MDD.

【 授权许可】

CC BY   
© The Author(s). 2017