Association between increased serum interleukin-8 levels and improved cognition in major depressive patients with SSRIs

BMC Psychiatry

Research

Huiping Zhang¹  Li Juan Man²  Zhen Hua Zhu²  Wen Long Hou²  Hong Liang Zhu²  Qiu Fang Jia²  Rong Hua Li²  Xu Yuan Yin²  Ru Feng Chen²  Jing Wang²  Li Hui³  Yuan Cai³ 

[1] Departments of Psychiatry and Medicine, Boston University Chobanian and Avedisian School of Medicine, 02118-2526, Boston, MA, USA;Research Center of Biological Psychiatry, Suzhou Guangji Hospital, Medical College of Soochow University, No. 11 Guangqian Road, 215137, Suzhou, Jiangsu, People’s Republic of China;School of Mental Health, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, People’s Republic of China;Research Center of Biological Psychiatry, Suzhou Guangji Hospital, Medical College of Soochow University, No. 11 Guangqian Road, 215137, Suzhou, Jiangsu, People’s Republic of China;

关键词: Major depressive disorder;    Interleukin-8;    Cognitive function;    SSRIs;   

DOI  :  10.1186/s12888-023-04616-z

 received in 2022-12-07, accepted in 2023-02-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe effect of neuroinflammatory cytokines on cognitive deficits in patients with major depressive disorder (MDD) can be altered by selective serotonin reuptake inhibitors (SSRIs). This study aimed to examine serum interleukin-8 (IL-8) levels, cognitive function, and their associations in MDD patients with SSRIs.MethodsThirty SSRI-treated MDD patients and 101 healthy controls were recruited for this study. We examined cognitive performance using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum IL-8 levels using the Human Inflammatory Cytokine Cytometric Bead Array in both cases and controls.ResultsThe RBANS test scores were significantly lower in MDD patients with SSRIs than in healthy controls after controlling for covariates (all p < 0.001). Serum levels of IL-8 were higher in MDD patients with SSRIs than in healthy controls after adjusting for covariates (F = 3.82, p = 0.05). Serum IL-8 levels were positively correlated with sub-scores of delayed memory (r = 0.37, p = 0.04) and visuospatial/constructional (r = 0.43, p = 0.02) in MDD patients with SSRIs but not in in healthy controls (delayed memory score: r = -0.12, p = 0.24; visuospatial/constructional score: r = 0.02, p = 0.81).ConclusionsOur findings suggested that increased serum IL-8 level might not only be involved in the MDD psychopathology or the use of SSRIs but also correspond to improving MDD delayed memory and visuospatial/constructional function.

【 授权许可】

CC BY   
© The Author(s) 2023

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