Combination with Red ginseng and Polygoni Multiflori ameliorates highfructose diet induced metabolic syndrome

BMC Complementary and Alternative Medicine

Research Article

Yun Jung Lee¹  Min Chul Kho¹  Dae Gill Kang²  Ho Sub Lee²  Jeong Dan Cha³  Kyung Min Choi³  Ji Hun Park⁴ 

[1] College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, 570-749, Jeonbuk, Korea;Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, 570-749, Jeonbuk, Korea;College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, 570-749, Jeonbuk, Korea;Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, 570-749, Jeonbuk, Korea;Brain Korea (BK)21 plus team, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, 540-749, Jeonbuk, Republic of Korea;Department of Research Development, Institute of Jinan Red Ginseng, Jinan, Korea;Hanbang Body-fluid Research Center, Wonkwang University, Shinyong-dong, Iksan, 570-749, Jeonbuk, Korea;

关键词: Red ginseng;    Polygoni Multiflori;    Metabolic syndrome;    Vascular inflammation;    Stetohepatitis;   

DOI  :  10.1186/s12906-016-1063-7

 received in 2015-11-11, accepted in 2016-02-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome such as dyslipidemia, hypertension, obesity, impaired glucose tolerance and fatty liver, can be caused by modification of diet by means of overconsumption of high fructose diet. This study was designed to investigate whether combination with Red ginseng and Polygoni Multiflori Radix (RGPM), widely used traditional herbal medicine, ameliorates on highfructose (HF) diet-induced metabolic syndrome.MethodsSD rats were fed the 60 % HF diet with/without rosiglitazone, and RGPM 100, 300 mg/kg/day, respectively. All groups received regular diet or HF diet, respectively, for 8 weeks. The last three groups treatment of rosiglitazone and RPGM orally for a period of 6 weeks.ResultsChronic treatment with RGPM significantly decreased body weight, fat weight and adipocyte size. RGPM significantly prevented the development of the metabolic disturbances such as hypertension, hyperlipidemia and impaired glucose tolerance. RGPM also led to increase in high density lipoprotein level in the HF group. RGPM suppressed high-fructose diet induced vascular inflammation marker expression such as adhesion molecules and ET-1 in aorta as well as increasing of C-reactive protein (CRP) levels in plasma. Similarly, RGPM attenuated hepatic lipid accumulation by inhibition of monocyte chemoattractant protein-1 (MCP-1) expression.ConclusionAn administration of RGPM may be a beneficial therapy for the treatment of metabolic syndrome through the improvement of hypertension, obesity, hyperlipidemia, vascular inflammation and insulin resistance.

【 授权许可】

CC BY   
© Kho et al. 2016