Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats

Journal of Pharmacological Sciences

Yeong-Ki Min¹  Mi-Hyeon Jang³  Seok-Hee Chung¹  Sung-Soo Kim¹  Min-Chul Shin³  Chang-Ju Kim³  Hyun-Dae Shin¹  Jong-Soo Lee¹  Baek-Vin Lim³  Ee-Hwa Kim² 

[1] Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University;Department of Meridianology, College of Oriental Medicine, Semyung University;Department of Physiology, College of Medicine, Kyung Hee University

关键词: Red ginseng;    treadmill exercise;    serotonin;   

DOI  :  10.1254/jphs.93.218

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(13)Red ginseng has been used as an ergogenic aid for endurance exercise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exercise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running, and Red ginseng treatment inhibited exercise-induced increases in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.

【 授权许可】

Unknown