Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study

BMC Cancer

Research Article

Jiliang Qiu¹  Binkui Li¹  Pinzhu Huang¹  Yunfei Yuan¹  Xiangming Lao¹  Ruhai Zou¹  Jian Hong¹  Shengping Li¹  Yun Zheng¹  Qing-An Zeng²  Yijie Li² 

[1] State Key Laboratory of Oncology in South China/Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, Guangdong, China;State Key Laboratory of Oncology in South China/Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, Guangdong, China;Department of General Surgery, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China;

关键词: Neoplasm;    Multiple primary;    Extrahepatic;    Hepatocellular carcinoma;    Prognosis;   

DOI  :  10.1186/1471-2407-12-148

 received in 2011-09-25, accepted in 2012-04-17,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe prolonged survival of individuals diagnosed with cancer has led to an increase in the number of secondary primary malignancies. We undertook to perform a definitive study to characterize and predict prognosis of multiple primary malignancies (MPM) involving hepatocellular carcinoma (HCC), due to the scarcity of such reports.MethodsClinicopathological data were analyzed for 68 MPM patients involving HCC, with 35 (target group) underwent curative liver resection. Additional 140 HCC-alone patients with hepatectomy were selected randomly during the same period as the control group.ResultsOf the 68 patients with extrahepatic primary malignancies (EHPM), 22 were diagnosed synchronously with HCC, and 46 metachronously. The most frequent EHPM was nasophargeal carcinoma, followed by colorectal and lung cancer. Univariate analysis demonstrated that synchronous (P = 0.008) and non-radical treatment for EHPM (P < 0.001) were significant risk factors associated with poorer overall survival (OS). While, Cox modeling revealed that the treatment modality for EHPM, but not the synchronous/metachronous determinant, was an independent factor for OS, and that therapeutic option for HCC was an independent factor for HCC-specific OS. Moreover, no HCC-specific overall and recurrence-free survival benefit were observed in the control group when compared with that of the target group (P = 0.607, P = 0.131, respectively).ConclusionsCurative treatment is an independent predictive factor for OS and HCC-specific OS, and should been taken into account both for synchronous and metachronous patients. MPM patients involving HCC should not be excluded from radical resection for HCC.

【 授权许可】

Unknown   
© Zeng et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.