Effect of green tea extracts on oxaliplatin-induced peripheral neuropathy in rats

BMC Complementary and Alternative Medicine

Research Article

Yoon Tae Kim¹  Jung Soo Lee¹  Young-Seok Cho²  Yoon Ho Ko³  Eun Kyoung Jeon³  Hye Sung Won³ 

[1] Department of Rehabilitation Medicine, Uijeongbu St. Mary's hospital, The Catholic University of Korea, Uijeongbu, South Korea;Division of Gastroenterology, Department of Internal Medicine, Uijeongbu St. Mary's hospital, The Catholic University of Korea, Uijeongbu, South Korea;Division of Oncology, Department of Internal Medicine, Uijeongbu St. Mary's hospital, The Catholic University of Korea, 65-1, Geumo-dong, 480-717, Uijeongbu- si, South Korea;

关键词: Oxaliplatin;    Peripheral neuropathy;    Green tea extract;    Antioxidant;   

DOI  :  10.1186/1472-6882-12-124

 received in 2011-09-25, accepted in 2012-08-05,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundA common side effect of oxaliplatin is peripheral neurotoxicity. Oxidative stress to dorsal root ganglion (DRG) may be one of important pathogenic mechanisms. Green tea contains four polyphenol catechins, which are known to be potent antioxidants. The present work is aimed to determine whether green tea extracts have neuroproective or palliative effects on neurotoxicity symptoms induced by oxaliplatin.MethodsWe conducted behavioral tests including sensory and thermal thresholds, an electrophysiological study, and TUNEL staining to assess neurotoxicity during the experimental period using animal models.ResultsA total of 14 adult rats were randomly allocated into two groups. Oxaliplatin (4 mg/kg) with or without green tea (300 mg/kg orally once daily) was administered intraperitoneally twice per week for 6 weeks. At 4 and 6 weeks after oxaliplatin administration, sensory threshold values were significantly decreased and at 6 weeks after oxaliplatin administration, thermal threshold values were significantly increased in oxaliplatin-treated rats compared with those in rat treated with oxaliplatin and green tea extracts. The electrophysiological assessment, including sensory nerve conduction and H-reflex-related sensory nerve conduction velocity, revealed no significant changes in the two groups. TUNEL staining showed no significant difference in the number of apoptotic-featured cells between the two experimental groups in the DRG or peripheral nerves, but the number of apoptotic-featured cells in DRG was higher than that in sciatic nerves within each group.ConclusionsGreen tea extracts may be a useful adjuvant to alleviate sensory symptoms after oxaliplatin administration, such as allodynia, but did not prevent morphometric or electrophysiological alterations induced by oxaliplatin.

【 授权许可】

Unknown   
© Lee et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.