Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia

BMC Neuroscience

Research Article

Cornelis J Stam¹  Elisabeth CW van Straaten¹  Willem de Haan²  Hanneke de Waal²  Ted Koene³  Philip Scheltens⁴  Wiesje M van der Flier⁵  Frederik Barkhof⁶ 

[1] Department of Clinical Neurophysiology, VU University Medical Center, de Boelelaan 1118, 1081, Amsterdam, HV, Netherlands;Department of Clinical Neurophysiology, VU University Medical Center, de Boelelaan 1118, 1081, Amsterdam, HV, Netherlands;Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands;Medical Psychology, VU University Medical Center, Amsterdam, Netherlands;Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands;Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands;Epidemiology & biostatistics, VU University Medical Center, Amsterdam, Netherlands;Radiology, VU University Medical Center, Amsterdam, Netherlands;

关键词: EEG;    Oscillations;    Spectral analysis;    Relative power;    Vascular dementia;    Cognition;    White matter;   

DOI  :  10.1186/1471-2202-13-85

 received in 2012-03-13, accepted in 2012-07-24,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundWhite matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SIVD-WMH) with 17 controls to investigate physiological changes underlying this diagnosis.ResultsDifferences between the groups were large, with a decrease of relative power of fast activity in patients (alpha power 0.25 ± 0.12 versus 0.38 ± 0.13, p = 0.01; beta power 0.08 ± 0.04 versus 0.19 ± 0.07; p<0.001) and an increase in relative powers of slow activity in patients (theta power 0.32 ± 0.11 versus 0.14 ± 0.09; p<0.001 and delta power 0.31 ± 0.14 versus 0.23 ± 0.09; p<0.05). Lower relative beta power was related to worse cognitive performance in a linear regression analysis (standardized beta = 0.67, p<0.01).ConclusionsThis pattern of disturbance in oscillatory brain activity indicate loss of connections between neurons, providing a first step in the understanding of cognitive dysfunction in SIVD-WMH.

【 授权许可】

CC BY   
© van Straaten et al.; licensee BioMed Central Ltd. 2012