期刊论文详细信息
BMC Cardiovascular Disorders
Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging
Research Article
Jehill D. Parikh1  Kieren G. Hollingsworth1  Andrew Blamire1  Vijay Kunadian2  Guy A. MacGowan3 
[1] Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK;Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK;Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK;Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK;Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK;
关键词: Pulse wave velocity;    Vicorder;    Phase contrast magnetic resonance imaging;    Ageing;   
DOI  :  10.1186/s12872-016-0224-4
 received in 2015-09-18, accepted in 2016-02-12,  发布年份 2016
来源: Springer
PDF
【 摘 要 】

BackgroundPulse wave velocity is an important measure of cardiovascular risk, and can be measured by several different techniques. We compared age-related changes in pulse wave velocity derived from carotid and femoral artery waveforms using the Vicorder device and descending thoracic aorta time velocity curves using phase contrast magnetic resonance imaging (MRI) in a group of normal healthy volunteers, without cardiovascular disease, aged between 20 and 79 years.MethodsEighty subjects underwent same-day measurements of Vicorder and MRI pulse wave velocity measurements.ResultsBoth Vicorder and MRI-based pulse wave velocity measurements were significantly increased with age (R = 0.59 and 0.57 respectively, both P < 0.0001). Vicorder and MRI pulse wave velocities were also significantly related to each other (R = 0.27, P < 0.05), and Bland Altman plots showed that on average Vicorder measurements were 1.6 m/s greater than MRI. In 5 % of cases, agreement between the values of the two techniques were above and below 2 standard deviations, and these were at higher levels of pulse wave velocities. Multiple linear stepwise regression analysis confirmed highly significant relationships of both techniques to age (both P < 0.0001), and MRI was also significantly related to heart rate (P = 0.006) but Vicorder was not.ConclusionsBoth Vicorder and MRI perform similarly in detecting age-related changes in pulse wave velocity. Thus, the choice of using one or the other will depend on other aspects of the investigation, such as the need for portability favouring Vicorder, or need for additional cardiovascular imaging favouring MRI.Trial registrationClinicalTrials.Gov identifier NCT01504828 

【 授权许可】

CC BY   
© Parikh et al. 2016

【 预 览 】
附件列表
Files Size Format View
RO202311091438529ZK.pdf 1177KB PDF download
【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  文献评价指标  
  下载次数:11次 浏览次数:1次