Role of inflammation in previously untreated macular edema with branch retinal vein occlusion

BMC Ophthalmology

Research Article

Katsunori Shimada¹  Tatsuya Mimura²  Hidetaka Noma³ 

[1] Department of Biostatistics, STATZ Institute Inc, Tokyo, Japan;Department of Ophthalmology, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan;Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women’s Medical University, 477-96, Owada-shinden, Yachiyo, Chiba, Japan;

关键词: Vascular Endothelial Growth Factor;    Macular Edema;    Macular Hole;    Retinal Vein Occlusion;    Triamcinolone Acetonide;   

DOI  :  10.1186/1471-2415-14-67

 received in 2014-02-14, accepted in 2014-05-08,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe association of inflammatory factors and the aqueous flare value with macular edema in branch retinal vein occlusion (BRVO) patients remains unclear. The relationship between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, soluble intercellular adhesion molecule 1 (sICAM-1), and soluble VEGF receptor-2 (sVEGFR-2) was evaluated to investigate the role of inflammation in BRVO associated with macular edema. Aqueous flare values and the vitreous levels of VEGF, IL-6, MCP-1, sICAM-1, and sVEGFR-2 were compared between previously untreated patients with BRVO and patients with macular hole (MH).MethodsVitreous samples were obtained from 45 patients during vitreoretinal surgery (28 patients with BRVO and 17 with MH), and the levels of VEGF, IL-6, MCP-1, sICAM-1, and sVEGFR-2 were measured by enzyme-linked immunosorbent assay. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion using fluorescein angiography and the Scion Image program. Aqueous flare values were measured with a laser flare meter and macular edema was examined by optical coherence tomography.ResultsThe median aqueous flare value was significantly higher in the BRVO group (12.1 photon counts/ms) than in the MH group (4.5 photon counts/ms, P < 0.001). There were significant correlations between the aqueous flare value and the vitreous levels of VEGF, IL-6, MCP-1, and sICAM-1 in the BRVO group (ρ = 0.54, P = 0.005; ρ = 0.56, P = 0.004; ρ = 0.52, P = 0.006; and ρ = 0.47, P = 0.015, respectively). The aqueous flare value was also significantly correlated with the foveal thickness in the BRVO group (ρ = 0.40, P = 0.037).ConclusionsInflammation may induce an increase of vascular permeability and disrupt the blood-aqueous barrier via release of inflammatory factors (VEGF, IL-6, MCP-1, and sICAM-1) in BRVO patients with macular edema.

【 授权许可】

CC BY   
© Noma et al.; licensee BioMed Central Ltd. 2014