Abiraterone acetate in metastatic castration-resistant prostate cancer – the unanticipated real-world clinical experience

BMC Urology

Research Article

Kuen Chan¹  T. W. Chan²  Henry Sze³  Michelle F. T. Chan³  Darren M. C. Poon⁴  Daisy Lam⁴  Eric K. C. Lee⁵  S. H. Lee⁶ 

[1] Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong;Hong Kong Society of Uro-Oncology (HKSUO), Hong Kong, Hong Kong;Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, Hong Kong;Hong Kong Society of Uro-Oncology (HKSUO), Hong Kong, Hong Kong;Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, Hong Kong;Hong Kong Society of Uro-Oncology (HKSUO), Hong Kong, Hong Kong;Department of Clinical Oncology, State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong;Hong Kong Society of Uro-Oncology (HKSUO), Hong Kong, Hong Kong;Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, Hong Kong;Hong Kong Society of Uro-Oncology (HKSUO), Hong Kong, Hong Kong;Department of Oncology, Princess Margaret Hospital, Hong Kong, Hong Kong;Hong Kong Society of Uro-Oncology (HKSUO), Hong Kong, Hong Kong;

关键词: Castration-resistant prostate cancer;    Abiraterone acetate;    Chemo-naïve;    Chemotherapy;    PSA response;   

DOI  :  10.1186/s12894-016-0132-z

 received in 2015-09-04, accepted in 2016-03-16,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThere is much interest in confirming whether the efficacy of abiraterone acetate (AA) demonstrated within the trial setting is reproducible in routine clinical practice. We report the clinical outcome of metastatic castration-resistant prostate cancer (mCRPC) patients treated with AA in real-life clinical practice.MethodsThe clinical records of mCRPC patients treated with AA from all 6 public oncology centers in Hong Kong between August 2011 and December 2014 were reviewed. The treatment efficacy and its determinants, and toxicities were determined.ResultsA total of 110 patients with mCRPC were treated with AA in the review period, of whom 58 were chemo-naive and 52 had received prior chemotherapy (post-chemo). The median follow-up time was 7.5/11.4 months for chemo-naive/post-chemo patients. 6.9/15.4 % of chemo-naive/post-chemo patients had visceral metastases. The median overall survival (OS) and progression-free survival (PFS) were 18.1/15.5 months and 6.7/6.4 months for chemo-naive/post-chemo patients, respectively. Among chemo-naive patients, those with visceral diseases had significantly inferior OS (2.8 vs 18.0 p = 0.0007) and PFS (2.8 vs 6.8 months, p = 0.0088) than those without. Pain control was comparable in both groups of patients. The most common grade 3 or above toxicities were hypertension (6.9/5.8 %) and hypokalemia (3.4/3.8 %) in chemo-naive/post-chemo patients. In multivariate analysis, the presence of prostate-specific antigen (PSA) response (≥50 % drop of PSA from baseline) within the first 3 months of therapy was associated with favorable OS and PFS in both chemo-naive and post-chemo group.ConclusionsIn clinical practice outside the trial setting, OS after AA in our chemo-naive patient cohort (18.1 months) was considerably shorter than that reported in the COU-AA-302 trial (34.7 months), and the OS was particularly short in those with visceral metastases (2.8 months). Conversely, AA was efficacious in post-chemo patients. AA resulted in comparable pain control in both groups of patients. The presence of PSA response within the first 3 months of treatment was a significant determinant of survival.

【 授权许可】

CC BY   
© Poon et al. 2016