Do body mass index trajectories affect the risk of type 2 diabetes? A case–control study

BMC Public Health

Research Article

Miri Sato¹  Ryoji Shinohara¹  Zentaro Yamagata²  Sonoko Mizorogi²  Atsunori Takahashi²  Kohta Suzuki²  Hiroshi Yokomichi³  Mie Mochizuki⁴  Yoshihiko Mano⁵  Masahiro Tsuji⁶  Yoshioki Yoda⁶ 

[1] Center for Birth Cohort Studies, Graduate School Department of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan;Department of Health Sciences, Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan;Department of Health Sciences, Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan;Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, UK;Department of Pediatrics, Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan;Department of Sports and Exercise Nutrition, School of Physical Education, Sendai University, Funaokaminami, 2-2-18, Shibata, Miyagi, Japan;Yamanashi Koseiren Health Care Center, 1-1-26 Iida, Kofu City, Yamanashi, Japan;

关键词: Diabetes mellitus, Type 2;    Body mass index;    Aging;    Blood glucose;    Hyperglycemina;    Hemoglobin A, Glycated;    Metabolic syndrome X;    General linear models;    Case–control studies;    Retrospective studies;   

DOI  :  10.1186/s12889-015-2073-y

 received in 2015-01-29, accepted in 2015-07-20,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAlthough obesity is a well-studied risk factor for diabetes, there remains an interest in whether “increasing body mass index (BMI),” “high BMI per se,” or both are the actual risk factors for diabetes. The present study aimed to retrospectively compare BMI trajectories of individuals with and without diabetes in a case–control design and to assess whether increasing BMI alone would be a risk factor.MethodsUsing comprehensive health check-up data measured over ten years, we conducted a case–control study and graphically drew the trajectories of BMIs among diabetic patients and healthy subjects, based on coefficients in fitted linear mixed-effects models. Patient group was matched with healthy control group at the onset of diabetes with an optimal matching method in a 1:10 ratio. Simple fixed-effects models assessed the differences in increasing BMIs over 10 years between patient and control groups.ResultsAt the time of matching, the mean ages in male patients and controls were 59.3 years [standard deviation (SD) = 9.2] and 57.7 years (SD = 11.2), whereas the mean BMIs were 25.0 kg/m2 (SD = 3.1) and 25.2 kg/m2 (SD = 2.9), respectively. In female patients and controls, the mean ages were 61.4 years (SD = 7.9) and 60.1 years (SD = 9.6), whereas the mean BMIs were 24.8 kg/m2 (SD = 3.5) and 24.9 kg/m2 (SD = 3.4), respectively. The simple fixed-effects models detected no statistical significance for the differences of increasing BMIs between patient and control groups in males (P = 0.19) and females (P = 0.67). Sudden increases in BMI were observed in both male and female patients when compared with BMIs 1 year prior to diabetes onset.ConclusionsThe present study suggested that the pace of increasing BMIs is similar between Japanese diabetic patients and healthy individuals. The increasing BMI was not detected to independently affect the onset of type 2 diabetes.

【 授权许可】

Unknown   
© Mano et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.