High prevalence of previous dengue virus infection among first-generation Surinamese immigrants in the Netherlands

BMC Infectious Diseases

Research Article

Anneke van den Hoek¹  Femke W Overbosch²  Gerard JB Sonder³  Janke Schinkel⁴ 

[1] Department of Infectious Diseases, Public Health Service (GGD), Nieuwe Achtergracht 100, 1018 WT, Amsterdam, The Netherlands;Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands;Department of Infectious Diseases, Public Health Service (GGD), Nieuwe Achtergracht 100, 1018 WT, Amsterdam, The Netherlands;National Coordination Centre for Traveller’s Health Advice (LCR), Amsterdam, The Netherlands;Department of Infectious Diseases, Public Health Service (GGD), Nieuwe Achtergracht 100, 1018 WT, Amsterdam, The Netherlands;National Coordination Centre for Traveller’s Health Advice (LCR), Amsterdam, The Netherlands;Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands;Department of Medical Microbiology, Section of Clinical Virology, Academic Medical Center, Amsterdam, The Netherlands;

关键词: Dengue;    Dengue virus infection;    DENV;    Seroprevalence;    Prevalence;    Suriname;    Americas;    Travellers;    VFRs;    Immigrants;   

DOI  :  10.1186/1471-2334-14-493

 received in 2014-01-08, accepted in 2014-09-02,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundA substantial portion of Dutch travellers is comprised of immigrants returning to their country of origin to visit friends and relatives (VFRs), including VFRs returning to dengue-endemic areas such as Suriname. Limited attention has been focused on dengue among immigrants, therefore it is unknown whether immigration has effect on the epidemiology of (severe) dengue among VFRs.To get more insight in the seroprevalence of dengue among Surinamese immigrants, we conducted a seroprevalence study on a convenience sample of first-generation Surinamese immigrants living in the Netherlands.MethodsBlood samples were tested for IgG antibodies to DENV antigen serotypes (1, 2, 3 and 4). Gender, age, years lived in Suriname before immigration, history of yellow fever vaccination, and time between yellow fever vaccination and blood sample collection were examined as possible predictors for previous infection.ResultsOf the studied 400 Surinamese travellers with a mean age of 52 years (range 18–89), 37% were male. Serology suggestive of past DENV infection was found in 325 individuals (81.3%; 95% CI: 77-85%). The time lived in Suriname before immigration was the only significant predictor for previous DENV infection.ConclusionsMost first-generation Surinamese immigrants have evidence of past DENV infection, probably comparable to Surinamese inhabitants. Whether this influences the number of cases of (severe) dengue when travelling requires more study.

【 授权许可】

CC BY   
© Overbosch et al.; licensee BioMed Central Ltd. 2014