CAMBer: an approach to support comparative analysis of multiple bacterial strains

BMC Genomics

Proceedings

Jerzy Tiuryn¹  Michal Wozniak²  Limsoon Wong³ 

[1] Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Poland;Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Poland;School of Computing, National University of Singapore, Singapore;School of Computing, National University of Singapore, Singapore;

关键词: Tuberculosis;    Multigene Family;    Refinement Procedure;    Annotate Gene;    Comparative Genomic Analysis;   

DOI  :  10.1186/1471-2164-12-S2-S6

来源: Springer

【 摘 要 】

BackgroundThere is a large amount of inconsistency in gene structure annotations of bacterial strains. This inconsistency is a frustrating impedance to effective comparative genomic analysis of bacterial strains in promising applications such as gaining insights into bacterial drug resistance.ResultsHere, we propose CAMBer as an approach to support comparative analysis of multiple bacterial strains. CAMBer produces what we called multigene families. Each multigene family reveals genes that are in one-to-one correspondence in the bacterial strains, thereby permitting their annotations to be integrated. We present results of our method applied to three human pathogens: Escherichia coli, Mycobacterium tuberculosis and Staphylococcus aureus.ConclusionsAs a result, more accurate and more comprehensive annotations of the bacterial strains can be produced.

【 授权许可】

CC BY   
© Wozniak et al; licensee BioMed Central Ltd. 2011