Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes - the PRIAMOS trial

BMC Cancer

Study Protocol

Lutz Edler¹  Klaus Herfarth¹  Florian Sterzing²  Sonja Krause²  Dirk Neuhof²  Juergen Debus² 

[1] Department of Biostatistics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany;Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany;

关键词: Prostate cancer;    Radiotherapy;    Hypofractionation;    Helical tomotherapy;    Prostate bed;    Pelvic lymph nodes;   

DOI  :  10.1186/1471-2407-12-504

 received in 2012-06-05, accepted in 2012-10-19,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundWhile evidence on safety and efficacy of primary hypofractionated radiotherapy in prostate cancer is accumulating, data on postoperative hypofractionated treatment of the prostate bed and of the pelvic lymph nodes is still scarce. This phase II trial was initiated to investigate safety and feasibility of hypofractionated treatment of the prostate bed alone or with the pelvic lymph nodes.Methods/designA total of 80 prostate cancer patients with the indication for adjuvant radiotherapy will be enrolled, where 40 patients with a low risk of lymph node involvement (arm 1) and another 40 patients with a high risk of lymph node involvement (arm 2) will each receive 54 Gy in 18 fractions to the prostate bed. Arm 2 will be given 45 Gy to the pelvic lymph nodes additionally. Helical Tomotherapy and daily image guidance will be used.DiscussionThis trial was initiated to substantiate data on hypofractionated treatment of the prostate bed and generate first data on adjuvant hypofractionated radiotherapy of the pelvic lymph nodes.Trial registrationClinicalTrials.gov; NCT01620710

【 授权许可】

CC BY   
© Krause et al.; licensee BioMed Central Ltd. 2012