A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts

BMC Complementary and Alternative Medicine

Research Article

Shahnaz Rahman¹  Mohammad Faisal¹  Rownak Jahan¹  Ahamed Ismail Hossain¹  Mohammed Rahmatullah² 

[1] Department of Biotechnology and Genetic Engineering, University of Development Alternative, 1209, Dhanmondi, Dhaka, Bangladesh;Department of Biotechnology and Genetic Engineering, University of Development Alternative, 1209, Dhanmondi, Dhaka, Bangladesh;University of Development Alternative, House No. 78, Road No. 11A (new), 1209, Dhanmondi, Dhaka, Bangladesh;

关键词: Antihyperglycemic;    Alternanthera sessilis;    Glucose tolerance;    Non-narcotic analgesic;    Amaranthaceae;   

DOI  :  10.1186/1472-6882-14-169

 received in 2014-03-25, accepted in 2014-05-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAlternanthera sessilis is used by folk medicinal practitioners of Bangladesh for alleviation of severe pain. The objective of this study was to scientifically analyze the analgesic (non-narcotic) property of aerial parts of the plant along with antihyperglycemic activity.MethodsAntihyperglycemic activity was measured by oral glucose tolerance tests. Analgesic (non-narcotic) activity was determined by observed decreases in abdominal writhings in intraperitoneally administered acetic acid-induced pain model in mice.ResultsAdministration of methanol extract of aerial parts led to dose-dependent and significant reductions in blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, the extract reduced blood sugar levels by 22.9, 30.7, 45.4 and 46.1%, respectively compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 48.9%. In analgesic activity tests, the extract at the above four doses reduced the number of abdominal writhings by 27.6, 37.9, 41.4, and 44.8%, respectively. A standard analgesic drug, aspirin, reduced the number of writhings by 31.0 and 51.7%, respectively, when administered at doses of 200 and 400 mg per kg body weight.ConclusionThe results validate the folk medicinal use of the plant to alleviate pain. At the same time, the antihyperglycemic activity result suggests that the plant may be a potential source for blood sugar lowering drug(s).

【 授权许可】

Unknown   
© Hossain et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.